Squarize Lab

The University of Michigan School of Dentistry

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ABOUT


In my laboratory of Epithelial Biology, we investigate the function of key molecular signaling pathways and the contribution of stem cells to epithelial regeneration and diseases present in the skin and oral mucosa. My research focuses on answering critical clinical questions and problems related to the healing of oral mucosa and skin, in addition to studying epithelial malignancies, particularly head and neck cancer.

CANCER (HNSCC)

cancer hnscc
Pullos & Squarize, JDR
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STEM CELL (EPITHELIAL)

stem cell
Squarize lab data
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TISSUE REGENERATION (STEM CELL - MUCOSA/SKIN)

tissue regeneration
Squarize et al, PLoSOne

DIRECTOR

Cristiane H. Squarize

Cristiane H. Squarize, DDS, MS, PhD
Associate Professor of Dentistry

[email protected] | 734-615-3406

Dr. Squarize is an Associate Professor with tenure and Principal Investigator of the Epithelial Biology Lab at the UM. She earned a DDS, followed by a Master’s degree and PhD in Oral Pathology. She won the prestigious Edward Hatton Award from the International Association for Dental Research for her head and neck cancer research. Before joining the University of Michigan in 2010, she completed her training and service on surgical and experimental pathology, followed by a five years fellowship at the National Institute of Dental and Craniofacial Research, focusing on Stem Cell Biology and Epithelial Biology, as well as Oral and Pharyngeal Cancer. Dr. Squarize is also a member of the Michigan Medicine Rogel Cancer Center and the Division Leader on the UM SoD Global Initiative.

Dr. Squarize established national and international collaborations to advance science and has mentored students from diverse backgrounds. The students in her laboratory are from many academic majors, including chemistry, biology, pharmacy, dentistry, medicine, computational science, among others. This interdisciplinary group of students and professionals works together towards the identification of solutions and novel treatments for epithelial cancers, and the promotion of regeneration of mucosa and skin.


We are determined to understand the function of the key signaling molecules and stem cells in epithelial regeneration and disease.

Our research uses cutting edge technology, combined with the use of in vitro studies and preclinical in vivo models, to solve critical clinical questions and problems related to healing of the oral mucosa and skin, as well as epithelial cancer progression and resistance to therapy.

PUBLICATIONS

SCIENTIFIC JOURNAL COVERS

cancer research cover
neoplasia cover
oral surgery cover
oral surgery cover
umich cover

BOOKS AND BOOK CHAPTERS

  • Cristiane H. Squarize and Rogerio M. Castilho. Emerging animal models. Current Methods in Medicinal Chemistry and Biological Physics. Edited by Carlton A. Taft , Carlos H. T. P. Silva. Research Signpost 207-226, 2007. ISBN: 81-308-0141-8
  • Cristiane H. Squarize, Rogerio M. Castilho and Andreia M. Leopoldino. Drug Target Validation. Current Methods in Medicinal Chemistry and Biological Physics. Vol. 2. Edited by Carlton A. Taft, Carlos H. T. P. Silva. Research Signpost 167-186, 2008. ISBN: 978-81-308-0292-3


View the complete list of publications

LAB TEAM

Cristiane H. Squarize

Cristiane H. Squarize, DDS, MS, PhD
Principal Investigator

Stella Jeng

Stella (Yeejin) Jang
Research Lab Technician

Larissa Rolim

Larissa Rolim
PhD Candidate

Caio Barros

Caio Barros
PhD Candidate

Joel Bonney

Joel Bonney
Research Lab Technician

LAB ALUMNI

Luciana O. Almeida, PhD
[email protected]

Thamara Bezerra DDS, MS

Gabriel A. Borges
[email protected]

Carolina Siviero Dillenburg, DDS, MS
[email protected]

Maria José Fernandez, DDS, PhD
[email protected]

Marisol Miranda Galvis, DDS, MS, PhD

Fernanda Giudice, DDS, MS
[email protected]

John M. Le, DDS
[email protected]

Manoela Domingues Martins, DDS, MS, PhD
[email protected]

Marco Antonio Trevizani Martins, DDS, MS, PhD
[email protected]

Ana Elizia Mascarenhas, DDS, MS

Camila Matsumoto, PhD
[email protected]

Alissa Pullos, DDS
[email protected]

Ericka J.D. Silveira

Glaucia Soares, DDS, MS

Vivian Petersen Wager, DDS, MS
[email protected]

Liana Preto Webber, DDS, MS
[email protected]

Brian Yip, DDS
[email protected]

Veronica Yujra DDS, MS

Chiara Zagni, PhD
[email protected]

CONTACT

Squarize Lab
University of Michigan School of Dentistry
1011 N University Ave, Room 6218
Ann Arbor, MI 48109
734-615-3406 | [email protected]
cristiane squarize at computer