Emrick Lab

The University of Michigan School of Dentistry

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ABOUT


The mouth provides us with remarkable sensations.


We bite into, adeptly manipulate, and crunch foods without inflicting self-injury. Our dentition and supporting structures routinely tolerate extreme forces of mastication, yet they also allow us to discern minuscule changes in bite and unanticipated hard particulates in food. We hardly notice these forces in normal chewing function; however, if the teeth are damaged and the dental pulps become inflamed, their sensory input is altered and we begin to experience excruciating pain – the toothache.

In thinking about these phenomena, we also wonder: What makes the tongue and lips profoundly sensitive to touch? How do common components (i.e., sensory neurons) provide us with unique sensations from distinct tissues? What makes our mouth feel dry? Why is tooth pain exquisite? And how do we inherently “know” the position of our teeth, jaws, and tongue when we eat and speak?

The Emrick lab is interested in answering these types of questions (and others) by studying the molecules, cells, and circuitry of the sensory nervous system innervating the mouth, head, and neck. In essence, we want to understand how it all encodes oral and craniofacial information, contributes to normal tissue function, and ultimately drives reflexes and perceptions.


Trigeminal ganglion imaging: Oral stimulation evokes response of sensory neurons

DIRECTOR

joshua Emrick

Joshua J. Emrick, DDS, PhD
Assistant Professor

jjemrick@umich.edu

Dr. Joshua Emrick is an assistant professor in the Department of Biologic and Materials Sciences & Prosthodontics at the University of Michigan School of Dentistry. He was awarded his D.D.S. and Ph.D. in oral and craniofacial biology from the University of California - San Francisco School of Dentistry, completing his dissertation with Dr. David Julius (Nobel Prize, 2021). Prior to joining Michigan, Dr. Emrick conducted his postdoctoral studies as a Dental Clinical Research Fellow at the National Institute of Dental and Craniofacial Research (NIDCR) with Dr. Nicholas Ryba.

Dr. Emrick is a U-M Biological Sciences Scholar (2021) and has support from a NIDCR Career Transition Award (K22). He is a member of Omicron Kappa Upsilon, and is the past recipient of the UC Regents Scholarship, Robert W. Rule Award (UCSF), Elizabeth Fuhriman Gardner Award (UCSF), Intramural Loan Repayment Program Award (NIH), Fellows Award for Research Excellence (NIH), and AADR Hatton Award.

PUBLICATIONS


View the listing of publications on Scopus.

TEAM

The Emrick lab is actively recruiting members to join our budding research group on Central Campus.

We will have open positions at the level of technician and postdoctoral fellow. These opportunities would be well-suited for recent college graduates interested in an immersive research experience and/or soon-to-be PhDs with degrees in neuroscience or biomedical sciences.

Importantly, lab members are expected contribute to a culture that embraces curiosity, integrity, excitement, respect, and cooperation. We will do our best to enjoy working hard together.

If you are excited about joining our group, please contact Dr. Joshua Emrick (jjemrick@umich.edu) with an up-to-date CV as well as a cover letter describing your research interest, relevant experience, and career goals. Feel free to forward as appropriate.

Mak Guenther

Mak Guenther
Lab Manager

meguenth@umich.edu

Brian Constantinescu

Brian Constantinescu
Undergraduate Student

conbri@umich.edu

Akash Gandhi

Akash Gandhi
Undergraduate Student

argandhi@umich.edu

NEWS

David Julius Wins Nobel Prize for Work on Pain Sensation

Oct 4, 2021 | UCSF News

David Julius, PhD, professor and chair of the Department of Physiology and Morris Herzstein Chair in Molecular Biology and Medicine at UC San Francisco, has won the 2021 Nobel Prize in Physiology or Medicine.

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Scorpion toxin that targets 'wasabi receptor' may help solve mystery of chronic pain

Sept 13, 2019 | Dentistry Today

Researchers at UC San Francisco and the University of Queensland have discovered a scorpion toxin that targets the "wasabi receptor," a chemical-sensing protein found in nerve cells that's responsible for the sinus-jolting sting of wasabi and the flood of tears associated with chopping onions.

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AADR STRIDES IN SCIENCE PROFILE

June 10, 2021 | AADOCR

Joshua Emrick is a scientist and dentist with an interest in oral somatosensation, particularly pain.

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BIOLOGICAL SCIENCES SCHOLARS PROGRAM

BSSP

The Biological Sciences Scholars Program (BSSP) provides start-up funds to recruit outstanding scientists in key areas of life sciences investigation. The goal of the program is to develop a new generation of leaders in bioscience research at the University of Michigan.

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CONTACT

Emrick Lab
University of Michigan School of Dentistry
1011 N University Ave,
Room 6223
Ann Arbor, MI 48109

Email: jjemrick@umich.edu
Telephone: (734) 763-1080
Fax: (734) 763-3453
Twitter: @jjemrick