Castilho Lab

Laboratory of Epithelial Biology



Our laboratory focus on the understanding of the “histone code” in the context of tissue injury, chronic inflammatory diseases, and cancer biology. We explore the role of histone acetylation and chromatin remodeling in the control of epithelial functions, including healing, maintenance of epithelial homeostasis and stem cell function. We also explore the epigenetic-driven mechanisms involved in tumor resistance to chemotherapy and ionizing radiation and focus on the use of “epi-drugs” to counteract cancer-driven histone modifications.

castilho lab microscopic image
active gene silenced gene image


rogerio castilho

Rogerio Castilho, DDS, MS, PhD
Associate Professor of Dentistry | 734-647-2150

Rogerio M. Castilho is an Associate Professor (with tenure) at the Department of Periodontics and Oral Medicine, and the Associate Chair for the Division of Oral Medicine, Oral Pathology and Radiology at the University of Michigan School of Dentistry. Dr. Castilho earned his DDS from the Catholic University of Campinas, and his MS and Ph.D. from the University of Sao Paulo, Brazil. Dr. Castilho joined the prestigious National Institute of Dental and Craniofacial Research (NIDCR) at the National Institutes of Health (NIH) as a post-doctoral fellow for near 7 years.

At the NIH, Dr. Castilho developed conducted a series of studies on the molecular mechanisms involved in the maintenance of epithelial and oral mucosa homeostasis and wound healing along with cancer biology. Currently, Dr. Castilho focuses on translation research to improve healing of burned patients through the modulation of signaling pathways involved in cellular migration and proliferation. For over 9 years, Dr. Castilho has also explored epigenetic modifications in head and neck cancers including salivary gland tumors that can be pharmacologically targeted using new emerging epi-drugs.


salivary gland tumors
Cancer Biology – Salivary Gland Tumors
head and neck squamous cell carcinoma
Cancer Biology – Head and Neck Squamous Cell Carcinoma (HNSCC)
periodonal disease
Epithelial Biology – Periodontal Disease
titanium toxicity
Epithelial Biology – Titanium Toxicity
Epithelial Biology – Wound Healing
Epithelial Biology – Wound Healing


The most recent publications are reported below.

View the complete list


rogerio castilho

Rogerio M. Castilho, DDS, MS, PhD

Principal Investigator

Carol Emericko

Carol Emerick

Visiting Scholar

Luan Cesar

Luan Cesar

Visiting Scholar

Joao Scarini

Joao Scarini

Visiting Scholar


Suzette D. Laing DDS, PhD

Leticia Drumond de Abreu Guimaraes

Carlos V. Nascimento Filho

Luciana O. Almeida, PhD

Allan Baker

Gabriell Bonifacio Borgato

Joao Artur Ricieri Brito, DDS, PhD

Carolina Siviero Dillenburg, DDS, MS

Anusha Etikala

Darcy Fernandes

Leticia Ferreira

Eduardo J. Gaio, DDS, MS, PhD

Pablo Galindo-Moreno, DDS, PhD

Carlos Andres Garaicoa, DDS

Fernanda Giudice, DDS, MS

Douglas M. Guimarães, DDS, PhD

Luciana Kauer, PhD

Renata Markman

Manoela Domingues Martins, DDS, MS, PhD

Marco Antonio Trevizani Martins, DDS, MS, PhD

Cuong Nguyen

Ana Carolina Pellicioli, DDS, MS

Leonardo Reis

Aaron Shin

Tobias Rauber Spuldaro

Fernando Suarez Lopez del Amo, DDS

Kellen Tjioe, DDS, MS, PhD

Vivian Petersen Wagner, DDS, MS

Liana Preto Webber, DDS, MS


Castilho Lab
University of Michigan School of Dentistry
1011 N. University, Room 2228 A, B, C,
Ann Arbor, MI 48109-1078
734-647-2150 |
castilho lab group