Castilho Lab

Laboratory of Epithelial Biology

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ABOUT

Our laboratory focus on the understanding of the “histone code” in the context of tissue injury, chronic inflammatory diseases, and cancer biology. We explore the role of histone acetylation and chromatin remodeling in the control of epithelial functions, including healing, maintenance of epithelial homeostasis and stem cell function. We also explore the epigenetic-driven mechanisms involved in tumor resistance to chemotherapy and ionizing radiation and focus on the use of “epi-drugs” to counteract cancer-driven histone modifications.


castilho lab microscopic image
active gene silenced gene image

DIRECTOR

rogerio castilho

Rogerio Castilho, DDS, MS, PhD
Associate Professor of Dentistry

[email protected] | 734-647-2150

Rogerio M. Castilho is an Associate Professor (with tenure) at the Department of Periodontics and Oral Medicine, and the Associate Chair for the Division of Oral Medicine, Oral Pathology and Radiology at the University of Michigan School of Dentistry. Dr. Castilho earned his DDS from the Catholic University of Campinas, and his MS and Ph.D. from the University of Sao Paulo, Brazil. Dr. Castilho joined the prestigious National Institute of Dental and Craniofacial Research (NIDCR) at the National Institutes of Health (NIH) as a post-doctoral fellow for near 7 years.

At the NIH, Dr. Castilho developed conducted a series of studies on the molecular mechanisms involved in the maintenance of epithelial and oral mucosa homeostasis and wound healing along with cancer biology. Currently, Dr. Castilho focuses on translation research to improve healing of burned patients through the modulation of signaling pathways involved in cellular migration and proliferation. For over 9 years, Dr. Castilho has also explored epigenetic modifications in head and neck cancers including salivary gland tumors that can be pharmacologically targeted using new emerging epi-drugs.

PROJECTS

salivary gland tumors
ACC tumor organoids
Cancer Biology – Salivary Gland Tumors
head and neck squamous cell carcinoma
Cancer Biology – Head and Neck Squamous Cell Carcinoma (HNSCC)
periodonal disease
Epithelial Biology – Periodontal Disease
titanium toxicity
Epithelial Biology – Titanium Toxicity
Epithelial Biology – Wound Healing
Epithelial Biology – Wound Healing

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PUBLICATIONS

The most recent publications are reported below.


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LAB PERSONNEL

rogerio castilho

Rogerio M. Castilho, DDS, MS, PhD

Principal Investigator

[email protected]

Carol Emericko

Carol Emerick

Visiting Scholar

[email protected]

Luan Cesar

Luan Cesar

Visiting Scholar

[email protected]

Joao Scarini

Joao Scarini

Visiting Scholar

[email protected]

Caio Barros

Caio Barros

Visiting Scholar

[email protected]

Juliana Amorim

Juliana Amorim

Visiting Scholar

[email protected]

Elisa Furquim

Elisa Furquim

Visiting Scholar

[email protected]

Gustavo Vieira

Gustavo Vieira

Visiting Scholar

[email protected]

Ana Colafemina

Ana Colafemina

Visiting Scholar

[email protected]

Luccas Lavareze

Luccas Lavareze

Visiting Scholar

[email protected]

Maria Leticia Lanca

Maria Leticia Lanca

Visiting Scholar

[email protected]

Mariana Pinto Ramos

Mariana Pinto Ramos

Visiting Scholar

[email protected]

Paulo Penafort

Paulo Penafort

Visiting Scholar

[email protected]

LAB ALUMNI

Suzette D. Laing DDS, PhD
[email protected]

Leticia Drumond de Abreu Guimaraes
[email protected]

Carlos V. Nascimento Filho
[email protected]

Luciana O. Almeida, PhD
[email protected]

Allan Baker
[email protected]

Gabriell Bonifacio Borgato
[email protected]

Joao Artur Ricieri Brito, DDS, PhD
[email protected]

Carolina Siviero Dillenburg, DDS, MS
[email protected]

Anusha Etikala
[email protected]

Darcy Fernandes
[email protected]

Leticia Ferreira
[email protected]

Eduardo J. Gaio, DDS, MS, PhD
[email protected]

Pablo Galindo-Moreno, DDS, PhD
[email protected]

Carlos Andres Garaicoa, DDS
[email protected]

Fernanda Giudice, DDS, MS
[email protected]

Douglas M. Guimarães, DDS, PhD
[email protected]

Luciana Kauer, PhD
[email protected]

Renata Markman

Manoela Domingues Martins, DDS, MS, PhD
[email protected]

Marco Antonio Trevizani Martins, DDS, MS, PhD
[email protected]

Cuong Nguyen
[email protected]

Ana Carolina Pellicioli, DDS, MS
[email protected]

Leonardo Reis

Aaron Shin
[email protected]

Tobias Rauber Spuldaro
[email protected]

Fernando Suarez Lopez del Amo, DDS
[email protected]

Kellen Tjioe, DDS, MS, PhD
[email protected]

Vivian Petersen Wagner, DDS, MS
[email protected]

Liana Preto Webber, DDS, MS
[email protected]

CONTACT

Castilho Lab
University of Michigan School of Dentistry
1011 N. University, Room 2228 A, B, C,
Ann Arbor, MI 48109-1078
734-647-2150 | [email protected]
castilho lab group