The University of Michigan School of Dentistry
As a translational research laboratory we seek to achieve predictable, personalized periodontal regeneration and wound healing despite local (i.e. occlusion, microbiological environment) and systemic confounding factors (i.e. diabetes, inflammatory burden). This will allow personalized regenerative treatment options for patients in the future, establishing care best suited for each individual.
Bone marrow/HSC niche regulation is one of the quintessential players in maintaining immunological and osteological homeostasis. HSC niche regulation is dependent on GAS6 secretion from osteoblasts to induce stem cell dormancy. Cancer cells can invade the HSC niche and receive the same GAS6 signal from osteoblasts. When GAS6 signaling is inhibited by adrenergic nerve products (i.e. norepinephrine), the cancer cells re-enter a proliferative cell cycle. As such, we are keen to characterize bone marrow biological mechanisms and discern how the adrenergic/GAS6 signaling axis affects other bone marrow biological components such as HSCs, immune cells, and skeletal remodeling cycles.
In order to fully deliver predictable, personalized dental care we must also understand what the host response factors are. Thus, one of our principal research goals is to better understand how the innate immune system can be trained and influenced by local/systemic mechanisms in the periodontium (i.e. alveolar bone, periodontal ligament, cementum, mucosa) in both health and disease.