Surface Lab

The University of Michigan School of Dentistry

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ABOUT

As we age, our quality of life critically depends on the skeletal and craniofacial bones, in both health and disease. The skeleton is not only of immense clinical importance, notably in the weakening of bones seen in osteoporosis, but also is a model for studying communication across organs, as bone cells help to coordinate many aspects of organismal homeostasis, including mineral metabolism, disruption of which can have major consequences for health. Research in the Surface Lab pursues addresses both aspects of bone health in aging and disease.

Our investigations focus on two main directions, united by similar methodologies of leveraging genome-wide approaches followed by molecular and organismal investigations, to understand the molecular responses of bone cells. The first direction focuses on the molecular mechanisms of bisphosphonates, commonly used drugs to treat osteoporosis. The second seeks to identity how cells in bone sense and respond to changes in serum phosphate concentration, with this response being key in the endocrine control of serum phosphate levels.

DIRECTOR

lauren surface

Lauren Surface, PhD
Assistant Professor

lsurface@umich.edu

Dr. Lauren Surface is an Assistant Professor in the Department of Biologic and Materials Sciences and Prosthodontics at the University of Michigan. She attended University of Washington for undergrad, performing research on yeast peroxisomes and fly brains. She then received her Ph.D. in Biology from the Massachusetts Institute of Technology, studying the role of chromatin in embryonic stem cell lineage commitment. Her postdoctoral research was done at Harvard University and Massachusetts General Hospital, setting the stage for opening her lab at the University of Michigan.

PUBLICATIONS


View the listing of publications on Scopus.

TEAM

Recruiting! Curious, enthusiastic, and kind researchers welcome!

Dylan Kuennen

Dylan Kuennen
Research Technician

dpkuenne@umich.edu

Hanah Kurosawa

Hanah Kurosawa
Undergrad Researcher

hakurosa@umich.edu

Helen SaTsu

Helen SaTsu
Undergrad Researcher

hsatsu@umich.edu

James Sugai

James Sugai
Lab Manager

jsugai@umich.edu

Lauren Surface

Lauren Surface
Assistant Professor

lsurface@umich.edu

CONTACT

Surface Lab
University of Michigan School of Dentistry
1011 N University Ave,
Room 3150
Ann Arbor, MI 48109

lsurface@umich.edu