Simmer Hu Lab

The University of Michigan School of Dentistry

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RESEARCH

The Simmer Hu laboratory studies tooth development, focusing on the human genetics of developmental anomalies of the dentition and using mouse models to understand how proteins encoded by genes function during normal tooth development and how their mutations lead to failures in such process.

The ultimate goal of our research is to apply scientific discoveries toward devising therapeutic measures for human disorders and diseases involving teeth.

The Simmer Hu lab played important parts in the first cloning of cDNA encoding enamelin (Enam), matrix metallowproteinase 20 (Mmp20) and kallikrein 4 (Klk4), and in the initial discoveries that MMP20, ITGB6 and FAM83H defects cause isolated amelogenesis imperfecta and that defects in FAM20A cause Enamel Renal Syndrome. These studies have greatly advanced our understanding of normal tooth development and associated disorders, leading to improvements in their diagnosis, prognosis and intervention.


simmer hu lab group photo

DIRECTORS

james simmer

James P. Simmer, DDS, PhD
Professor, Biologic and Materials Sciences & Prosthodontics

jsimmer@umich.edu | (734) 764-4676

Dr. Simmer is Professor in the Department of Biologic and Material Sciences. He received his DDS degree from the University of Michigan School of Dentistry in 1980, and received his PhD in Biochemistry from Wayne State University School of Medicine in 1990. He also did post-doctoral training with Dr. Hal Slavkin, at the Center for Craniofacial Molecular Biology in the University of Southern California School of Dentistry in Los Angeles, California. Before coming to Michigan, Dr. Simmer was an Associate Professor in the Dept. of Pediatric Dentistry at the University of Texas Health Science Center at San Antonio.

Dr. Simmer possesses excellent research and teaching credentials. His research interests are in the area of tooth development, enamel and dentin formation, biochemistry and molecular biology of amelogenins, and hypophosphatasia and amelogenesis imperfecta.

jan hu

Jan C.C. Hu, BDS, PhD
Samuel D. Harris Collegiate Professor of Dentistry
Chair, Biologic and Materials Sciences & Prosthodontics

janhu@umich.edu | (734) 763-6769

Dr. Hu completed her Bachelor of Dental Surgery degree from National Taiwan University in 1985. She earned a specialty certificate in pediatric dentistry and a PhD in craniofacial biology (1990) at the University of Southern California, completed a postdoctoral fellowship in craniofacial molecular biology and held the position of clinical assistant professor. In 1993, she joined the Department of Pediatric Dentistry at the University of Texas Health Science Center in San Antonio where she was promoted to the rank of associate professor with tenure in 1999.

Dr. Hu joined the U-M School of Dentistry in 2002 as an associate professor with tenure. In 2005 she was named the director of pediatric dentistry and in 2006 was promoted to full professor. She directs the Oral Health Sciences PhD program since November 2010. Dr. Hu’s research concentrates on tooth development and dental genetics; her clinical research interests focus on pulp biology and therapy.

PROJECTS

PUBLICATIONS

The most recent publications are reported below via Scopus search. View the complete list of publications of Dr. James Simmer and the complete list of publications of Dr. Jan Hu.

LAB TEAM

james simmer

James P. Simmer, DDS, PhD
Professor, Biologic and Materials Sciences & Prosthodontics

jsimmer@umich.edu

jan hu

Jan C. C. Hu, BDS, PhD
Samuel D. Harris Collegiate Professor of Dentistry
Chair, Biologic and Materials Sciences & Prosthodontics

janhu@umich.edu

charles smith

Charles E. Smith
Adjunct Research Scientist
Professor, Department of Anatomy & Cell Biology, Faculty of Medicine, McGill University

charles.smith@mcgill.ca

yuanyuan hu

Yuanyuan Hu, PhD
Research Laboratory Specialist Lead

yyhu@umich.edu

chuhua zhang

Chuhua Zhang, BMD
Research Lab Technician Lead

chuhuaz@umich.edu

lisa hong zhang

Lisa Hong Zhang, PhD
Postdoctoral Fellow

zhanghon@umich.edu

tian liang

Tian Liang, BDS, PhD
Postdoctoral Fellow

tianl@umich.edu


ALUMNI & COLLABORATORS

stephanie munez

Stephanie Núñez, DDS, PhD
Ideal Dental Solutions
Arlington, VA

yuhe lu

Yuhe Lu, DDS, MS, PhD
Orthodontics & Dentofacial Orthopedics
Boston, MA

jung-wook kim

Jung-Wook Kim, DDS, PhD
Department of Molecular Genetics
Department of Pediatric Dentistry & Dental Research Institute
School of Dentistry, Seoul National University

figen seymen

Prof. Dr. Figen Seymen
Istanbul University, Faculty of Dentistry, Department of Pediatric Dentistry

yong-hee chun

Yong-Hee Chun, DDS, MS, PhD
Assistant Professor, UT Health
San Antonio, TX

lorenza donnelly

Lorenza A. Donnelly, DDS
UNC Adams School of Dentistry
Chapel Hill, NC

curtis herzog

Curtis C. Herzog
Dental Student, University of Michigan School of Dentistry
Ann Arbor, MI

amelia richardson

Amelia S Richardson, DDS
Private Practice
Mount Pleasant, MI

shih-kai wang

Shih-Kai Wang, DDS, PhD
Assistant Professor, National Taiwan University
Taipei City, Taiwan

yasuo yamakoshi

Yasuo Yamakoshi, PhD
Professor, Tsurumi University School of Dentistry
Tsurumi, Japan

jack jie yang

Jack Jie Yang, DDS, PhD
Clinical Assistant Professor, Pediatric Dentistry

CONTACT

Simmer Hu Lab
Dental Research Lab
University of Michigan School of Dentistry
1210 Eisenhower Place
Ann Arbor, MI 48108
Phone: (734) 764-4676
Lab: (734) 764-4678
Email: janhu@umich.edu