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lombaert lab
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Develop the next generation of therapies and help the field of regenerative medicine move forward

RESEARCH

You don’t realize the importance of saliva until it’s gone.

The question that is driving our research in the long-term focuses on how we can apply stem cell-based therapies to repair damaged tissues.

We would like to determine how stem cells participate in the formation of branching organs and how they respond to various external and internal cues in normal, damaged or diseased environments. With this knowledge we then design ways to (re)generate new tissues and/or injured organs.

A particular area of the lab is focused on patients suffering from saliva loss, termed hypo-salivation, which can lead to dry mouth syndrome or xerostomia. This often painful and devastating oral health condition can occur in head-and-neck cancer patients receiving radiation on their salivary glands as part of radiotherapy treatment, or as a result of auto-immune diseases like Sjögren, or from the intake of certain medications.

With respect to those patients, we aim to team up with other experts in the field to define what is biologically and molecularly occurring in the damaged tissue, and define regenerative therapies that can be translated into the clinic.


With thanks to the following funding organizations:

NIDCR logo
Mich Pitt Wyss logo
michigan dentistry logo
biointerfaces logo
rogel cancer center logo
rackham logo

student performing research

PUBLICATIONS


SCIENTIFIC JOURNALS

The most recent publications are reported below or view the complete listing on Pubmed.


BOOKS & BOOK CHAPTERS

surgery of salivary glands book cover
regenerative medicine book cover
stem cells of craniofacial development book cover
salivary glands book cover
dry mouth book cover
stem cell therapy book cover

Surgery of the Salivary Glands

Witt, RL ed. Surgery of the Salivary Glands, Elsevier Publishers, London, England 2020.

Salivary Gland Regeneration – Appendix 5: Considering applications for regenerative medicine

Lombaert I.M.A. 2014
In: NIH Intramural Pluripotent Stem Cell Protocol Book
Editors: Hunsberger J., Becker S., and Rao M.

Stem cells in salivary gland development and regeneration

Lombaert I.M.A., Hoffman M.P. 2013
In: Stem cells in craniofacial development, regeneration, and repair
Editors: George H. and Irma T.

Epithelial stem/progenitor cells in the embryonic mouse submandibular gland

Lombaert I.M.A., Hoffman M.P. 2010
In: Salivary glands: Development, Adaptations and Disease. Frontiers of Oral Biology
Editors: Tucker A. and Miletich, I.

Is regeneration of diseased salivary glands a reasonable approach?

Coppes R.P., Lombaert I.M.A., 2010
In: Dry Mouth, The Malevolent Symptom: A Clinical Guide.
Editors: Screenby L. and Vissink A

Regeneration of irradiated salivary glands by stem cell therapy

Lombaert I.M.A. 2008
Drukkerij van Denderen, Groningen, The Netherlands. ISBN. 978-90-367-3370-0

TEACHING & OUTREACH


TEACHING

DENT 511: The Oralfacial Complex in Health II – The Oral Environment

This graduate level course is designed to provide the fundamental concepts of the oral environment that include salivary glands, oral mucosa and skin, as well as an introduction to the oral microbial ecology. It also introduces the role of oral health in dysfunctions and pathologies.


OUTREACH

NEWS

White Board: Stem Cells 101

ON THE LOOKOUT

March 2021 - The University of Michigan School of Dentistry is rated as the top dental school in the United States for the seventh consecutive year, and moved up to No. 2 in the world based upon academic reputation, employer reputation and research impact. Read more at UM Dentistry News.

March 2016 - University of Michigan School of Dentistry ranked 4th best in the world based on research citations per paper and employer and academic reputation

March 2016 - Dr. Lombaert speaks at AADR (American Association for Dental Research), Los Angeles, CA

isabelle lombaert

GROUP

isabelle lombaert
Photography by CJ South, MI

Isabelle Lombaert, PhD

Principal Investigator
lombaert@umich.edu

Dr. Lombaert earned her BSc and MSc in Bio-Engineering at Ghent University, Belgium. She next graduated with a PhD in Medical Sciences at the University Medical Center Groningen, The Netherlands. Prior to joining the University of Michigan she worked at the National Institutes of Health, Bethesda, MD as a Visiting and Research Fellow.


harleen athwal

Harleen Athwal
DDS/PhD Graduate Student

athwalhk@umich.edu

ashley cornett

Ashley Cornett, M.S. Biology
Research Laboratory Technician Senior

arieck@umich.edu

allison goodsell

Allison Goodsell
Undergraduate Research Assistant, Biology, Health, and Society, LSA

goodsela@umich.edu

Christina Jones

Christina Jones
DDS/PhD Graduate Student

cejone@umich.edu

Sanjana Kumar

Sanjana Kumar
Undergraduate Research Assistant, Biomolecular Science, LSA

sanaku@umich.edu

Hareesh Ragav

Hareesh Ragav
Undergraduate Research Assistant, Biopsychology, Cognition, and Neuroscience, LSA

hareesh@umich.edu

Abigail Vallie

Abigail Vallie
Research Laboratory Technician

vallie@umich.edu

Priyan Weerappuli, PhD

Priyan Weerappuli, PhD
Post-doctoral Research Fellow

pweerapp@umich.edu


LAB ALUMNI

Emily Hill

George Murphy III

Alex Carson

Fatima Haidar

Kenji Yeoh

Joe Nguyen

Shannon Achille

CONTACT

biointerfaces building

Office of Dr. Lombaert
Biointerfaces Institute
Blg. 14, Rm 117
2800 Plymouth Road
Ann Arbor 48104, MI

Phone: (+1) 734-763-1135
Fax: (+1) 734-763-7133
Email: lombaert@umich.edu

biointerfaces institute

Lab
Biointerfaces Institute
Blg. 20W, Rm 334W
2800 Plymouth Road
Ann Arbor 48104, MI

Phone: (+1) 734-763-1135

school of dentistry

School of Dentistry
Dept. of Biologic and Materials Sciences
1011 N. University Ave.
Ann Arbor 48109, MI

Phone: (+1) 734-763-5280
Fax: (+1) 734-763-3453

lab team