The University of Michigan School of Dentistry
Research in our laboratory is focused on understanding cellular and molecular mechanisms that regulate physiological and pathological bone metabolism, skeletal and craniofacial bone development and diseases. In particular, we are interested in the following lines of research:
Autophagy is a conserved lysosomal degradation process that has important roles in both normal human physiology and disease. However, the function of autophagy in skeletal and craniofacial bone homeostasis is not well understood. We found that autophagy is activated during osteoblast differentiation. Ablation of FIP200 (focal adhesion kinase family interacting protein of 200 kD), an essential component of mammalian autophagy, leads to multiple autophagic defects in osteoblasts. Osteoblast-specific deletion of FIP200 leads to osteopenia in mice. Our current effort is to determine the molecular mechanisms and signaling pathways by which autophagy regulates mesenchymal stem cell, craniofacial osteogenic stem cell and osteoblast function using a combination of molecular, cell biological and mouse genetic approaches.
Tuberous sclerosis (TS) is a genetic disorder characterized by the presence of benign congenital tumors in multiple organs and is caused by mutations in one of two genes, called TSC1 and TSC2. Tuberous sclerosing bone dysplasia is characterized by osteosclerotic changes in skeletal and craniofacial bones. In this disease, hyperactivity of mTOR (mammalian target of rapamycin) signaling is implicated. Despite the high frequency of osseous manifestation (>66%) in TSC patients, it is unknown to what extent and how mTOR signaling regulates bone metabolism in vivo. We established the first craniofacial sclerotic bone lesion mouse model of Tuberous sclerosis and found that enhanced mTOR signaling in neural crest-derived cells can increase bone mass through enlargement of the osteoprogenitor pool, which likely explains the sclerotic bone lesion observed in Tuberous sclerosis patients. We are currently using various genetic mouse models to elucidate the mechanisms by which mTOR signaling regulates skeletal and craniofacial bone development.
FAK (Focal adhesion kinase) is a major mediator of signal transduction by integrins. We recently demonstrated that FAK deletion in osteoblast progenitor cells leads to an osteopenia phenotype associated with increased bone marrow adiposity. The decreased bone mass in FAK-deficient mice is accounted for by decreased proliferation, compromised osteogenic differentiation, and increased adipogenic differentiation of bone marrow mesenchymal stromal/stem cells. Mechanistically, FAK deficiency leads to decreased Wnt/β-catenin signaling evidenced by lowered β-catenin protein levels and decreased mRNA expression of Wnt ligands and target genes. Our findings demonstrated that FAK plays an important role in bone mass acquisition and also identified a novel mechanism accountable for the negative correlation between bone mass and bone marrow adiposity. We are currently determining the function of FAK in mesenchymal stem cells and the impact of FAK inhibition on bone health.
feiliu@umich.edu | | 734-936-0911
2022-present | Interim Chair, Department of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry |
2021-present | Interim Program Director, Graduate Prosthodontics, University of Michigan School of Dentistry |
2020-2022 | Associate Chair of Prosthodontics, Department of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry |
2018-2021 | member, Executive Committee, University of Michigan School of Dentistry |
2018-present | Chair, PhD admission Committee, Oral Health Science Program, University of Michigan School of Dentistry |
2016-present | member, PhD candidate Preliminary Exam Committee, University of Michigan School of Dentistry |
2012-2018 | member, Research Committee, University of Michigan School of Dentistry |
2021-present | Member, DEI committee, American Society for Bone and Mineral Research |
2020-present | Member, American Dental Education Association |
2018-present | Member, program committee, International Chinese Musculoskeletal Research Society |
2017- 2020 | Board Director, American Academy of Fixed Prosthodontics |
2013-2018 | Chair, Tylman Research Committee of American Academy of Fixed Prosthodontics |
2012-present | Member, International Association of Dental Research |
2012-2015 | Member, Constitution Committee, American Association of Dental Research |
2012-present | Member, American Association of Dental Research |
2012-2014 | Chair, Scientific Research Committee of American Academy of Fixed Prosthodontics |
2012-present | Member, Research Committee, American College of Prosthodontists |
2010-present | Fellow, American College of Prosthodontists |
2009-present | Member, International Chinese Musculoskeletal Research Society (Lifetime member from 2017) |
2008-2013 | Member, Tylman Research Committee of American Academy of Fixed Prosthodontics |
2007-present | Member, American Academy of Fixed Prosthodontics |
2004-present | Member, American Society for Bone and Mineral Research |
2021 | Fellow, American Society for Bone and Mineral Research |
2010 | Fellow, American College of Prosthodontists |
2004 | First place of Remo Sinibaldi Memorial Table Clinic Competition, American College of Prosthodontics |
2004 | ASBMR Young Investigator Award from American Society for Bone and Mineral Research |
2004 | Young Investigator Award, Advances in Skeletal Anabolic Agents for the Treatment of Osteoporosis (American Society for Bone and Mineral Research) |
1998 | First place of DENTSPLY dental graduate student scholarship, West China University of Medical Sciences (Si Chuan University) |
1997 | First place of Xuan Rui Ling dental graduate student scholarship, West China University of Medical Sciences (Si Chuan University) |
Travel Award from American Society for Bone and Mineral Research to Dr. Fang Fang (post-doc fellow)
Travel Award from American Society for Bone and Mineral Research to Dr. Li Wang (post-doc fellow)
1. ASBMR Young Investigator Award from American Society for Bone and Mineral Research to Dr. Xiaoxi Wei (PhD student)
2. Plenary oral presentation and ASBMR Young Investigator Award from American Society for Bone and Mineral Research to Dr. Chunhui Sun (visiting scholar)
1. AADR student research fellowship to Neil Thomas (DDS candidate)
2. Travel Award from American Society for Bone and Mineral Research to Dr. Han Kyoung Choi (post-doc fellow)
1. Janice E. Berry Prize for Excellence in Research to Dr. Xiaoxi Wei (visiting scientist)
2. 2nd place in Basic Science Research, University of Michigan School of Dentistry Annual Research Day to Dr. Yuanlynn Hsieh (MS student)
3. Travel Award at second annual musculoskeletal symposium from Michigan Integrative Musculoskeletal Health Core Center to Dr. Jinfeng Yao (visiting scholar)
1. 1st place in Basic Science Research, University of Michigan School of Dentistry Annual Research Day to Dr. Yuanlynn Hsieh (MS student)
2. 1st place in Visiting Scholar Research to Dr. Xiaoxi Wei at University of Michigan School of Dentistry Annual Research Day (visiting scholar)
3. 2nd place in Visiting Scholar Research to Dr. Bei Yin at University of Michigan School of Dentistry Annual Research Day (visiting scholar)
4. 3rd place in Visiting Scholar Research to Dr. Shuqun Qi at University of Michigan School of Dentistry Annual Research Day (visiting scholar in Dr. Liu’s lab)
5. 3rd place in basic science research at University of Michigan School of Dentistry Annual Research Day to Dr. Han Kyoung Choi (research fellow)
6. Delta dental fellowship award to 2019 dental student graduates at University of Michigan School of Dentistry to Neil Thomas (DDS research pathway student)
7. Young Investigator Travel Award from American Society for Bone and Mineral Research to Shuqun Qi (PhD student)
8. Young Investigator Travel Award from American Society for Bone and Mineral Research to Dr. Han Kyoung Choi (post-doc fellow)
1. 2nd place in Basic Science Research, University of Michigan School of Dentistry Annual Research Day to Di Xie (U of M undergraduate student, 2024 DDS class)
2. 2nd place in Visiting Scholar Research to Dr. Shuqun Qi at University of Michigan School of Dentistry Annual Research Day (visiting PhD student)
3. 3rd place in Visiting Scholar Research to Dr. Yating Wang at University of Michigan School of Dentistry Annual Research Day (visiting scholar)
4. ASBMR Young Investigator Award from American Society for Bone and Mineral Research to Shuqun Qi (PhD student)
1. Outstanding PhD thesis award from Stomatological Association of SiChuan to Shuqun Qi (PhD student)
2. ASBMR Young Investigator Award for ECTS Digital Masterclass, American Society for Bone and Mineral Research to Shuqun Qi (post-doc fellow)