Translational Immunology Research To Improve Oral Health
A Member of the Cancer Moonshot℠ IOTN
"We are a member of the Cancer Moonshot℠ Immuno-Oncology Translational Network (IOTN). We are dedicated to helping patients with high-risk oral leukoplakia and oral cancer. We welcome inquiries for opportunities for getting involved in our translational and clinical research programs."
Pattern Recognition Receptors (PPRs) constitute the first line of defense against “non-self” antigens, which are encountered during microbial infections and cancer development. With the characterization of new PRR families, such as Toll-like receptors (TLRs), NOD-like receptors (NLRs), RIG-I-like receptors (RLRs) and cGAS-STING-mediated cytoplasmic DNA-sensing molecules, novel regulatory mechanisms of PRR signaling are rapidly emerging as main cancer immune escape mechanisms. We pioneered in the identification of novel PRR regulators. Our laboratory has developed a unique collection of toolkits in the following areas.
Emerging evidence suggests that PRR not only detect molecular structures associated with pathogens but those linked to cellular and tissue damage. Due to increased genome instability in cancer cells and chemoradiation therapy, PRR-mediated sensing of cytoplasmic DNA, a classic danger signal for cellular damage, triggers the production of chemokines that recruit immune cells to the tumor bed. But this process is frequently suppressed by squamous cell carcinomas, leading to immune escape. We are among the first to show that oncogenic signaling in squamous cell carcinomas suppresses PRRs as a key mechanism driving T-cell exclusion.
With the emerging combinatorial strategies for cold cancer, precise identification of this group of tumors is essential for the selection of optimal treatment protocols. In collaboration with a computational geneticist, we have developed a robust and novel immune-cell deconvolution machine learning tool to map the landscape of tumor-infiltrating lymphocytes.
Cold cancers are featured by insufficient elicitation of tumor-specific T-cell immunity. In order to expand the tumor-specific CD8+ T-cell repertoire, our group utilizes advanced nanotechnologies to deliver and optimize the intra-lesional immune microenvironment. For example, we have shown that our nano-vaccines can sensitize cold tumors to immunotherapy, and a combination of nano-vaccines with checkpoint blockade leads to significantly expanded tumor-specific effector T cells, reduced T-cell exhaustion and better tumor control.
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Dr. Lei is an immunologist-oral pathologist. He is an Assistant Professor of Dentistry, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry. He is a faculty member of the Translational Oncology Program, Head and Neck Oncology Program, Cancer Biology Program, the Graduate Program in Immunology, and the U-M Comprehensive Cancer Center, University of Michigan School of Medicine. After his Ph.D. training at the Lineberger Comprehensive Cancer Center, UNC-Chapel Hill, and residency at the University of Pittsburgh Medical Center, he completed his Head and Neck Oncology research fellowship at the University of Pittsburgh Cancer Institute. Before he was recruited to U-M, he served as a research track faculty member at the Department of Otolaryngology University of Pittsburgh School of Medicine.
Dr. Lei is certified by the American Board of Oral and Maxillofacial Pathology (ABOMP); and participates in the University of Michigan Oral Pathology Biopsy Service. He serves on the editorial board of the official journal of ABOMP, Oral Surgery Oral Medicine Oral Pathology Oral Radiology. He is a recipient of the Leon Barnes award from the United States and Canadian Academy of Pathology and the NIH/NIDCR Dentist-Scientist Pathway to Independence Award. He is enthusiastically committed to teaching, molecular immunology and oral health research, and clinical service in the community.
We are seeking a highly motivated postdoctoral research fellow to join our research laboratory at the University of Michigan Rogel Cancer Center (UMRCC) at North Campus Research Complex (NCRC). We are a translational immunology group that has made pioneering discovery on the mechanisms driving cancer resistance to immunotherapy. We are a member of the national Immuno-Oncology Translational Network. The NIH funded positions will address significant questions at the interface of cancer immunotherapy and metabolism. Our research group employs a spectrum of cutting-edge genetic, single-cell, and immune engineering approaches to identify novel mechanisms driving cancer immune escape and sensitize cold cancers to immune checkpoint blockade. Our laboratory is well-equipped with close collaborations with scientists across various disciplines.
NCRC is a major U-M initiative that is providing a platform for highly accomplished investigators to make transformational advances in oncology. UMRCC at NCRC currently comprises 30 investigators, 19 of whom are located in Building 520. UMRCC at NCRC will ultimately include upwards of 40 investigators representing 10 schools and institutes across the University, eight of these 10 are ranked in the top ten nationally. UMRCC at NCRC researchers are characterized by a track record of high impact discoveries, significant levels of NIH peer-reviewed funding, a demonstrated commitment to team science, an entrepreneurial spirit, potential for interaction with biotechnology hubs at the NCRC and a demonstrated dedication to translating basic research findings into clinical applications.
The successful candidate should be a recent Ph.D. graduate with a degree in Immunology, Cancer Biology, Genetics, Metabolism, or Cell and Molecular Biology. Individuals with expertise in mouse models or immunology are strongly encouraged to apply.
We are accepting students from PIBS and Oral Health Science PhD programs. We welcome any inquiries regarding rotations and collaborations.
Dr. Gong is a PhD candidate in the State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University. He is a joint-training PhD student in Dr. Lei's laboratory of translational immunology. His research interest is to identify novel oncogenic signaling that leads to oral cancer and oral pre-malignancy immune escape.
Blake is a PhD student within the Graduate Program in Immunology. He graduated from Texas Christian University with a Bachelor of Science degree in Biology. Prior to graduate school, he held research positions at UT Southwestern, as a Research Technician in the Department of Pharmacology, and at Baylor College of Medicine / Texas Children's Hospital as a Postbaccalaureate Research Education Program (PREP) Student.
Dr. Hossain is a postdoctoral research fellow in Dr. Lei’s lab of translational immunology. He received his Bachelor’s in Pharmacy and Master’s in Pharmacy from University of Dhaka, Bangladesh, and later received his Ph.D. in Medicinal Chemistry from the University of Toledo, OH with a research emphasis on the optimization of cancer vaccines and immune checkpoint inhibitors. Dr. Hossain will participate in a project that characterizes the oncogenic inhibition of innate immune sensing of tumors, which serves as a pivotal mechanism underpinning the resistance to immunotherapy. He will be working with members from an interdisciplinary group to enhance immunoprevention strategies.
Dr. Lin is a postdoctoral research fellow in Dr. Lei's laboratory. He graduated from Peking University Health Science Center with a Bachelor of Science degree in Basic Medical Science. Then, he received his Ph.D. degree in Immunology from Peking University Health Science Center. Xin is interested in understanding how oral epithelial dysplasia and oral cancer escape from immunosurveillance by depriving metabolic support from immune cells. He will utilize genetic modeling and a spectrum of molecular immunology techniques to identify the underpinnings of tumor resistance to immunotherapy.
Dr. Luo is a second-year PhD candidate in the State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University. Presently, he is a joint-training PhD student in Dr. Lei's lab. He is interested in understanding how type 1 interferon signaling regulates the immunogenicity of oral cancer and exploring novel approaches to enhance host anti-tumor immunity.
Leah is the lab manager of our group. She received her Bachelor of Science in Life Sciences from Peking University, where she conducted research projects on the interaction between the type I interferon pathway and inflammasome activation. Leah is working with the team to characterize novel mechanisms underpinning oral cancer immune escape and to develop immune engineering approaches that sensitize cold tumors to immunotherapy.
Denise Barrak [2017-2018]
Shuyun Ge, DDS, PhD [2017-2018]
Yee Sun Tan, PhD [2016-2019]
Lei Lab of Translational Immunology
1600 Huron Parkway, Lab 2411
Ann Arbor 48105, MI
Phone: (734) 764-0003
University of Michigan Oral Pathology Biopsy Service
1011 N University Ave, G018
Ann Arbor 48109, MI
Phone: (800) 358-1011