Hatch Lab

The University of Michigan School of Dentistry

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ABOUT

The Hatch laboratory studies craniofacial skeletal development, using mouse models for genetic and epigenetic study, identification and phenotyping of developmental changes and cell biologic defects underlying craniosynostosis and cranial base defects.

We strive to delineate molecular defects in essential developmental pathways to ultimately provide improved prognostic indicators and medical treatment options for patient with craniofacial abnormalities.


binucleation of cells image

Image shows increased tendency for binucleation due to cytokinesis defects in TNAP (Tissue Nonspecific Alkaline Phosphatase) deficient cells. We are investigating TNAP as an essential regulator of mesenchymal progenitor cell renewal and cell metabolism, in addition to its previously established role as a mediator of matrix mineralization.

DIRECTOR

nan hatch

Nan Hatch, DMD, PhD
Associate Professor of Dentistry
Lysle E. Johnston, Jr. Collegiate Professor of Orthodontics
Chair, Department of Orthodontics and Pediatric Dentistry

nhatch@umich.edu | (734) 647-6567

Dr. Hatch completed her Doctor of Medicine in Dentistry from Harvard University in 1999. She earned an orthodontic clinical specialty certificate (2002) and a PhD in Molecular and Cell Biology (2005) from the University of Washington in Seattle. She completed a postdoctoral fellowship as a trainee on the institutional Tissue Engineering and Regeneration (TEAM) T32 training grant at the University of Michigan, School of Dentistry. She was hired as an Assistant Professor of Dentistry at the University of Michigan in 2008 and became a tenured Associate Professor of Dentistry in 2015.

Dr. Hatch became the Lysle E. Johnston, Jr. Collegiate Professor of Orthodontics and Chair of the Department of Orthodontics and Pediatric Dentistry in 2016. Dr. Hatch’s research concentrates on craniofacial skeletal development with a goal of identifying primary mediators and modifiers of abnormal craniofacial skeletal development. She also works to establish biologic mediators for control of orthodontic tooth movement and retention.


EDUCATION

1990 BS, Psychology, Tufts University, Medford MA
1999 DMD, Harvard School of Dental Medicine, Boston MA
2002 Orthodontic Certificate, University of Washington, Seattle WA
2005 PhD, Molecular and Cell Biology, University of Washington, Seattle WA

ACADEMIC APPOINTMENTS AND PROFESSIONAL EXPERIENCE

2003-2004 Teaching Assistant, Biochemistry, University of Washington, Seattle, WA
2005-2008 Research Fellow, Tissue Engineering and Regeneration T32, School of Dentistry, University of Michigan, Ann Arbor, MI
2008-2015 Assistant Professor, Department of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, MI
2015-2019 Research Director, Division of Orthodontics, School of Dentistry, University of Michigan, Ann Arbor, MI
2015- Lysle E Johnston, Jr. Collegiate Professor of Orthodontics and Associate Professor of Dentistry
2016- Chair, Department of Orthodontics and Pediatric Dentistry, University of Michigan, Ann Arbor, MI

PUBLICATIONS

The most recent publications are reported below.

View the complete list

LAB PERSONNEL

Hwa Kyung Nam
Research Specialist

Identifying Modifiers and Primary Mediators of Phenotype Severity in Craniosynostosis.
Neural Crest Specific Knockout of TNAP to Establish TNAP as Essential Regulator of Craniofacial Stem Cells in Development.

hknam@umich.edu

Iva Vesela
Postdoctoral Fellow

Potential Rescue of Craniofacial Abnormalities by Arqule in the Mouse Model of Crouzon Syndrome.
Determine Mechanisms by which FGFR2 Mediates Craniosynostosis in Alpl-/- Mouse Model of Hypophosphatasia.

vesela@umich.edu

Erica Siimets
DDS/PhD Student

Paraxial Mesoderm vs. Cranial Neural Crest Cell Effects of Craniosynostosis associated FGFR2C342Y Mutation

esiis@umich.edu

Manos Emmanouil
MS Student

Alpl-/- Mouse Model of Hypophosphatasia
Does Elimination of Enpp1 Rescue Craniofacial Bone Abnormalites in Alpl-/- Mouse Model of Hypophosphatasia?

manosemm@umich.edu

Josh Padonova
MS Student

FGF2 Treatment for Rescue of Bone Mineralization in Alpl-/- Mouse Model of Hypophosphatasia.

jdpadov@umich.edu

Derrick Crawford
MS Student

Investigating Inflammatory Mediators in Microspheres to Control Tooth Movement.

derrcraw@umich.edu

Jack Dominic Toor
UM Undergraduate Student

Paraxial Mesoderm vs. Cranial Neural Crest Cell Effects of Craniosynostosis associated FGFR2C342Y Mutation

toorj@umich.edu

CONTACT

Hatch Lab
University of Michigan School of Dentistry
1011 N University Ave, Room 4208
Ann Arbor, MI 48109