The University of Michigan School of Dentistry
Our laboratory’s main goal is to explore the potential of novel methods for growth factor delivery, such as gene therapy, for restoring periodontal tissue lost due to oral disease. Working with investigators at the College of Engineering, we are able to immobilize PDGF and BMP adenoviral vectors onto various biomaterials for soft tissue and bone regeneration in vivo.
We also are investigating ways to improve outcomes for patients with implants. In addition to our studies examining increased implant osseointegration, we are researching new methods to incorporate periodontal ligament with alveolar bone and titanium.
Finally, the lab has been involved in clinical research studies that analyze oral fluids (whole saliva, crevicular fluid) in order to identify predictive markers of gingivitis, periodontal disease progression and peri-implant bone loss. By combining the levels of specific biomarkers together with the expression levels of certain bacteria within patient plaque samples, we are able to better determine the patient’s disease status resulting in a more effective treatment plan.
Our laboratory is exploring the potential of novel methods of growth factor delivery such as gene therapy to stimulate periodontal tissue repair.
wgiannob@umich.edu | 734-763-2105
Dr. William Giannobile is the Najjar Endowed Professor & Chair of the Department of Periodontics and Oral Medicine at the University of Michigan School of Dentistry. He is also a Professor of Biomedical Engineering at the College of Engineering. He received his DDS and MS in Oral Biology from the University of Missouri. He later received his Certificate in Periodontology and Doctor of Medical Sciences in Oral Biology from Harvard University. He completed postdoctoral training in Molecular Biology at the Dana-Farber Cancer Institute and Harvard Medical School. Dr. Giannobile previously served as a faculty member at Harvard and the Forsyth Institute. He has served as a Visiting Professor at the University of Genoa Medical School Biotechnology Institute and in the Department of Periodontology at the Eastman Dental Institute, University College London.
Dr. Giannobile’s continuously NIH funded research program over the past 20 years has focused on Oral and Periodontal Regenerative Medicine, Tissue Engineering and Personalized Medicine. Dr. Giannobile currently serves as the Editor-in-Chief for the Journal of Dental Research, the official journal of the International Association for Dental Research. He is a past-president of the American Academy of Periodontology Foundation. Dr. Giannobile is a consultant to the U.S. Food and Drug Administration for Dental Devices. He is a Fellow of the American Association for the Advancement of Science (AAAS) and a Fellow of the American and International Colleges of Dentists. He currently serves as the Co-Principal Investigator of the NIH-funded Michigan-Pittsburgh-Wyss Regenerative Medicine Resource Center that focuses on the translation of regenerative technologies to the clinical arena. Dr. Giannobile is a diplomate of the American Board of Periodontology and participates in a practice limited to periodontics and implant dentistry in Ann Arbor.
Alyssa Moy wins undergraduate first prize at BioInterfaces Research Day microposter session
William Giannobile awarded 2018 Norton M. Ross Award by the American Dental Association: ADA News
Dr. Giannobile and Dr. Kohn receive grant for new regenerative medicine center: M-Dentistry News
Dr. Giannobile helps pioneer new approach to dental care: M-Dentistry News
DentNEWS: Dr. Giannobile named new JDR editor-in-chief
Gene therapy to treat gum disease: U-M News Service
The future of periodontology: An interview with Dr. William Giannobile and Dr. Pamela Robey
Growth rate of replacement blood vessels, tissues: U-M News Service
Gene therapy promising for growing tooth-supporting bone: U-M News Service
Hermann Agis
hermann.agis@meduniwien.ac.at
Salvatore Batia
salvomarioclaudio@yahoo.it
Po Chun Chang
changpc@ntu.edu.tw
Young Dan Cho
cacodm@hanmail.net
Jong-Hyuk Chung
Kyung Hee University, Seoul, Korea
Joni Cirelli
cirelli@foar.unesp.br
Roberto Farina
roberto.farina@unife.it
Tobias Fretwurst
tobias.fretwurst@uniklinik-freiburg.de
Lukas Furhauser
lukas.fuerhauser@gmx.at
Reinhard Gruber
reinhard.gruber@meduniwien.ac.at
Jie Hao
hjie@umich.edu
Qiming Jin
jinqm@umich.edu
Frederic Kauffmann
fkauffma@umich.edu
Nolan Kavanagh
nolankav@umich.edu
Laura Kruger
krulaura@umich.edu
Zhao Lin
zlin@vcu.edu
Julie Marchesan
Julie_Marchesan@unc.edu
Alberto Monje
amonjec@umich.edu
Trang Nguyen
nvnt.dds@gmail.com
Andrea Ottonello
andrea8nello@gmail.com
Chan Ho Park
chanho@umich.edu
Gaia Pelligrini
gaiapellegrini.perio@gmail.com
Sophia Pilipchuk
spilipch@med.umich.edu
Alexandra Plonka
aplonka@umich.edu
Angeliki Polymeri
polyan@umich.edu
Christoph Ramsier
christoph.ramseier@zmk.unibe.ch
Stefan Schroeckmair, Bernhard Gottlieb University Clinic of Dentistry, Vienna, Austria
Yang-Jo Seol
yjseol@snu.ac.kr
Seung-Yun Shin
ssyislet@khu.ac.kr
Mario Taba, Jr.
mtaba@forp.usp.br
Valeria Tedeschi
valeriapontelli@forp.usp.br
Kemal Ustun
k_ustun@yahoo.com
Christian Wehner, Bernhard Gottlieb University Clinic of Dentistry, Vienna, Austria
Andreas Weisbauer
andreasweisbauer@hotmail.com
Jinping Xu
jpxu@umich.edu
Ning Yu
niyu@umich.edu
Erin Shan Huey Yu
shanhyu@umich.edu
Giannobile Lab
Dept. of Periodontics and Oral Medicine
Biointerfaces Institute
NCRC Bldg 20, Rm 334W-02
2800 Plymouth Road
Ann Arbor 48104, MI
Phone: 734-763-7103
Fax: 734-763-5503