Giannobile Lab

The University of Michigan School of Dentistry



Our laboratory’s main goal is to explore the potential of novel methods for growth factor delivery, such as gene therapy, for restoring periodontal tissue lost due to oral disease. Working with investigators at the College of Engineering, we are able to immobilize PDGF and BMP adenoviral vectors onto various biomaterials for soft tissue and bone regeneration in vivo.

We also are investigating ways to improve outcomes for patients with implants. In addition to our studies examining increased implant osseointegration, we are researching new methods to incorporate periodontal ligament with alveolar bone and titanium.

Finally, the lab has been involved in clinical research studies that analyze oral fluids (whole saliva, crevicular fluid) in order to identify predictive markers of gingivitis, periodontal disease progression and peri-implant bone loss. By combining the levels of specific biomarkers together with the expression levels of certain bacteria within patient plaque samples, we are able to better determine the patient’s disease status resulting in a more effective treatment plan.

Our laboratory is exploring the potential of novel methods of growth factor delivery such as gene therapy to stimulate periodontal tissue repair.


william giannobile

William V. Giannobile, DDS, MS, DMSc
Najjar Endowed Professor of Dentistry and Biomedical Engineering | 734-763-2105

Dr. William Giannobile is the Najjar Endowed Professor & Chair of the Department of Periodontics and Oral Medicine at the University of Michigan School of Dentistry. He is also a Professor of Biomedical Engineering at the College of Engineering. He received his DDS and MS in Oral Biology from the University of Missouri. He later received his Certificate in Periodontology and Doctor of Medical Sciences in Oral Biology from Harvard University. He completed postdoctoral training in Molecular Biology at the Dana-Farber Cancer Institute and Harvard Medical School. Dr. Giannobile previously served as a faculty member at Harvard and the Forsyth Institute. He has served as a Visiting Professor at the University of Genoa Medical School Biotechnology Institute and in the Department of Periodontology at the Eastman Dental Institute, University College London.

Dr. Giannobile’s continuously NIH funded research program over the past 20 years has focused on Oral and Periodontal Regenerative Medicine, Tissue Engineering and Personalized Medicine. Dr. Giannobile currently serves as the Editor-in-Chief for the Journal of Dental Research, the official journal of the International Association for Dental Research. He is a past-president of the American Academy of Periodontology Foundation. Dr. Giannobile is a consultant to the U.S. Food and Drug Administration for Dental Devices. He is a Fellow of the American Association for the Advancement of Science (AAAS) and a Fellow of the American and International Colleges of Dentists. He currently serves as the Co-Principal Investigator of the NIH-funded Michigan-Pittsburgh-Wyss Regenerative Medicine Resource Center that focuses on the translation of regenerative technologies to the clinical arena. Dr. Giannobile is a diplomate of the American Board of Periodontology and participates in a practice limited to periodontics and implant dentistry in Ann Arbor.


View the complete listing of publications by Dr. Giannobile


Welcome to the Giannobile Lab

Alyssa Moy wins undergraduate first prize at BioInterfaces Research Day microposter session

William Giannobile awarded 2018 Norton M. Ross Award by the American Dental Association: ADA News

Dr. Giannobile and Dr. Kohn receive grant for new regenerative medicine center: M-Dentistry News

Dr. Giannobile helps pioneer new approach to dental care: M-Dentistry News

DentNEWS: Dr. Giannobile named new JDR editor-in-chief

Gene therapy to treat gum disease: U-M News Service

The future of periodontology: An interview with Dr. William Giannobile and Dr. Pamela Robey

Growth rate of replacement blood vessels, tissues: U-M News Service

Gene therapy promising for growing tooth-supporting bone: U-M News Service


william giannobile

William V. Giannobile, DDS, DMSc
Principal Investigator

jim sugai

Jim Sugai
Research Laboratory Specialist Senior

alyssa moy

Alyssa Moy
Undergraduate Student

Caroline Schmiedeler

Caroline Schmiedeler
Undergraduate Student

lea sarment

Lea Sarment
Dental Student

kristen lehner

Kristen Lehner
Dental Student

Riccardo DiGianfilippo

Riccardo DiGianfilippo
Periodontics MS Student

lorenzo tavelli

Lorenzo Tavelli
Periodontics MS Student

larissa steigmann

Larissa Steigmann
Periodontics MS Student

andrea ravida

Andrea Ravida
Periodontics MS Student

lena larsson

Lena Larsson
Visiting Scholar

yao yao

Yao Yao
OHS PhD Student

qiming jin

Qiming Jin
Clinical Associate Professor

jeff wang

Jeff CW Wang
Clinical Assistant Professor

matt galli

Matt Galli

nitin kinra

Nitin Kinra

shayan barootchi

Shayan Barootchi

shogo Maekawa

Shogo Maekawa


Salvatore Batia

Po Chun Chang

Young Dan Cho

Jong-Hyuk Chung
Kyung Hee University, Seoul, Korea

Joni Cirelli

Roberto Farina

Lukas Furhauser

Jie Hao

Qiming Jin

Frederic Kauffmann

Nolan Kavanagh

Laura Kruger

Zhao Lin

Julie Marchesan

Alberto Monje

Trang Nguyen

Andrea Ottonello

Chan Ho Park

Sophia Pilipchuk

Alexandra Plonka

Angeliki Polymeri

Stefan Schroeckmair, Bernhard Gottlieb University Clinic of Dentistry, Vienna, Austria

Yang-Jo Seol

Seung-Yun Shin

Mario Taba, Jr.

Valeria Tedeschi

Kemal Ustun

Christian Wehner, Bernhard Gottlieb University Clinic of Dentistry, Vienna, Austria

Andreas Weisbauer

Jinping Xu

Ning Yu

Erin Shan Huey Yu


Giannobile Lab
Dept. of Periodontics and Oral Medicine
Biointerfaces Institute
NCRC Bldg 20, Rm 334W-02
2800 Plymouth Road
Ann Arbor 48104, MI

Phone: 734-763-7103
Fax: 734-763-5503