The University of Michigan School of Dentistry
The Fontana/González Lab and Clinical Research Unit's main goal is to increase our understanding of dental caries and improve its clinical management.
The research team conducts in vitro and clinical studies. Currently, several clinical studies assessing different strategies for caries risk assessment in children and evaluating non-operative management of cavitated caries lesions in young children are being conducted. In the in vitro side, numerous studies evaluating different caries preventive strategies in a variety of chemical and biofilm models are being conducted.
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Dr. González-Cabezas is a Professor in the Department of Cariology, Restorative Sciences and Endodontics and the Richard Christiansen Collegiate Professor of Oral and Craniofacial Global Initiatives at the University of Michigan School of Dentistry. He is also the Director of Global Initiatives in Oral and Craniofacial Health at the same institution.
Dr. González-Cabezas is regularly engaged in numerous research projects; many of them in collaboration with other institutions from all over the world. Dr. González has particular interest in secondary caries, dental erosion-abrasion, remineralization, fluorides, and oral health products in general (e.g., dentifrices, rinses, toothbrushes, etc.).
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Margherita Fontana, DDS, PhD, is the Clifford Nelson Endowed Professor of Dentistry in the Department of Cariology, Restorative Sciences and Endodontics at University of Michigan School of Dentistry (U-M). She is currently co-director of Cariology courses, and cariology discipline co-coordinator at U-M. As a principal investigator, she has received research grants from the National Institutes of Health, the Centers for Medicare and Medicaid, the American Association of Pediatric Dentistry, the Delta Dental Fund, DentaQuest, and private industry amongst others. She has over 125 papers published in peer reviewed journals, such as Journal of Dental Research, Caries Research, Journal of Dental Education, Pediatric Dentistry, Advances in Dental Research, Journal of Public Health Dentistry, Journal of the American Dental Association, British Dental Journal, etc. She was the 2007-2008 President of the Cariology Group of the International Association for Dental Research (IADR), and the 2010-2011 Chair of the Cariology Section of ADEA. In 2012 she received the USA Presidential Early Career Award for Scientists and Engineers (PECASE) for her work on caries risk assessment in children. She was the 2009 winner of the IADR Cariology Research Group’s Basil G. Bibby Award in Cariology, and in 2016 winner of the IADR Burrows Memorial Award.
Dental caries, one of the most common chronic diseases of childhood, is a largely preventable disease, yet approximately 23% of U.S. children 2-5 years-of-age experience dental caries, and this number more than doubles to 56% among those aged 6-8. In the current environment of escalating healthcare costs and resource constraints, the large disparities in caries experience and access to care that exist in the U.S., especially among low socioeconomic status (SES) and minority population groups, call for a greater focus on targeted (at the patient and tooth surface level), risk-based caries preventive and therapeutic strategies to be delivered through interprofessional partnerships, including primary healthcare settings.READ FULL ABSTRACT
This trial is a Phase III, multisite, randomized, placebo-controlled trial, with two parallel groups. The groups are SDF or placebo and they are applied every 6 months. The primary hypothesis of the trial is that SDF is better than placebo for stopping cavities with dentin exposed in baby teeth when assessed at 6 months after initial application.READ FULL ABSTRACT
The purpose of this study is to compare standard fillings and silver diamine fluoride (SDF) for treatment of cavities in baby teeth. The investigators will compare the effectiveness of stopping the cavity, cost of the treatments and the opinions of the families and the dental providers.READ FULL ABSTRACT