We are determined to understand the function of the key signaling molecules and stem cells in epithelial regeneration and disease.
Our research combines cutting edge technology using in vitro studies and preclinical models aiming to solve important clinical questions and problems related healing of the oral mucosa and skin, as well as, epithelial cancer progression and resistance to therapy.
Head of Laboratory
|2003 - 2010||Post-Doctorate, National Institutes of Health (NIH), USA|
|2003 - 2005||PhD, Oral Pathology, University of Sao Paulo, Brazil|
|2001 - 2003||MS, Oral Pathology, University of Sao Paulo, Brazil|
|1989 - 1995||DDS, Pontific Catholic University of Campinas, Brazil|
|Honors and Awards|
|2015||Robert Wood Johnson Foundation – AMFDP Scholar|
|2003 - 2005||Fellowship award for post-doctoral training, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH)|
|2003||Fellowship award for PhD education, FAPESP (Foundation for the support of research from the State of Sao Paulo)|
|2002||Unilever Travel Award, International Association of Dental Research (IADR), 80th Meeting of the International Association for Dental Research/AADR/CADR|
|2001 - 2003||Fellowship award for Master of Science education, FAPESP (Foundation for the support of research from the State of Sao Paulo)|
|2001||Edward H Hatton, IADR Brazilian Division - (First Prize) - Brazilian Society of Dentistry for research (SBPqO)|
|Academic Appointments and Professional Experience|
|2015 - present||Global Initiative Leader – Brazilian division – UM School of Dentistry Global Initiative|
|2010 - present||Assistant Professor, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA|
|2003 - 2010||Research Fellow at the National Institutes of Health (NIH), USA|
|2001 - 2003||Surgical and Experimental Pathology training and service, University of Sao Paulo, Sao Paulo, Brazil|
|1996 - 2001||Dental Surgeon, Proprietor, Private Practice, Campinas, Brazil|
The most recent publications reported below from pubmed. Visit Dr. Squarize's pubmed page for the complete list of publications.
Epigenetic Modifications and Head and Neck Cancer: Implications for Tumor Progression and Resistance to Therapy.
Int J Mol Sci. 2017 Jul 12;18(7):
Authors: Castilho RM, Squarize CH, Almeida LO
Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer and one of the most aggressive malignancies worldwide. Despite continuous efforts to identify molecular markers for early detection, and to develop efficient treatments, the overall survival and prognosis of HNSCC patients remain poor. Accumulated scientific evidences suggest that epigenetic alterations, including DNA methylation, histone covalent modifications, chromatin remodeling and non-coding RNAs, are frequently involved in oral carcinogenesis, tumor progression, and resistance to therapy. Epigenetic alterations occur in an unsystematic manner or as part of the aberrant transcriptional machinery, which promotes selective advantage to the tumor cells. Epigenetic modifications also contribute to cellular plasticity during tumor progression and to the formation of cancer stem cells (CSCs), a small subset of tumor cells with self-renewal ability. CSCs are involved in the development of intrinsic or acquired therapy resistance, and tumor recurrences or relapse. Therefore, the understanding and characterization of epigenetic modifications associated with head and neck carcinogenesis, and the prospective identification of epigenetic markers associated with CSCs, hold the promise for novel therapeutic strategies to fight tumors. In this review, we focus on the current knowledge on epigenetic modifications observed in HNSCC and emerging Epi-drugs capable of sensitizing HNSCC to therapy.
PMID: 28704968 [PubMed - in process]
Dr. Cristiane Squarize, an assistant professor in the Department of Periodontics and Oral Medicine, received the award which is designed to increase the number of faculty from diverse backgrounds who have the potential to reach positions of influence in academic medicine or dentistry, and who will serve as role models and be mentors to students with similar backgrounds. Read the full article