ABOUT

Squarize Lab's research interests

We are determined to understand the function of the key signaling molecules and stem cells in epithelial regeneration and disease.

Our research combines cutting edge technology using in vitro studies and preclinical models aiming to solve important clinical questions and problems related healing of the oral mucosa and skin, as well as, epithelial cancer progression and resistance to therapy.

Cancer (HNSCC)

Pullos & Squarize, JDR
Stem Cell (epithelial)

Squarize lab data
Tissue regeneration (Stem cell - Mucosa/Skin)

Squarize et al, PLoSOne

DIRECTOR

Cristiane H. Squarize, DDS, MS, PhD

Head of Laboratory

Education
2003 - 2010 Post-Doctorate, National Institutes of Health (NIH), USA
2003 - 2005 PhD, Oral Pathology, University of Sao Paulo, Brazil
2001 - 2003 MS, Oral Pathology, University of Sao Paulo, Brazil
1989 - 1995 DDS, Pontific Catholic University of Campinas, Brazil
Honors and Awards
2015 Robert Wood Johnson Foundation – AMFDP Scholar
2003 - 2005 Fellowship award for post-doctoral training, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH)
2003 Fellowship award for PhD education, FAPESP (Foundation for the support of research from the State of Sao Paulo)
2002 Unilever Travel Award, International Association of Dental Research (IADR), 80th Meeting of the International Association for Dental Research/AADR/CADR
2001 - 2003 Fellowship award for Master of Science education, FAPESP (Foundation for the support of research from the State of Sao Paulo)
2001 Edward H Hatton, IADR Brazilian Division - (First Prize) - Brazilian Society of Dentistry for research (SBPqO)
Academic Appointments and Professional Experience
2015 - present Global Initiative Leader – Brazilian division – UM School of Dentistry Global Initiative
2010 - present Assistant Professor, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA
2003 - 2010 Research Fellow at the National Institutes of Health (NIH), USA
2001 - 2003 Surgical and Experimental Pathology training and service, University of Sao Paulo, Sao Paulo, Brazil
1996 - 2001 Dental Surgeon, Proprietor, Private Practice, Campinas, Brazil

SCIENTIFIC JOURNAL COVERS

BOOKS AND BOOK CHAPTERS

  • Cristiane H. Squarize and Rogerio M. Castilho. Emerging animal models. Current Methods in Medicinal Chemistry and Biological Physics. Edited by Carlton A. Taft , Carlos H. T. P. Silva. Research Signpost 207-226, 2007. ISBN: 81-308-0141-8
  • Cristiane H. Squarize, Rogerio M. Castilho and Andreia M. Leopoldino. Drug Target Validation. Current Methods in Medicinal Chemistry and Biological Physics. Vol. 2. Edited by Carlton A. Taft, Carlos H. T. P. Silva. Research Signpost 167-186, 2008. ISBN: 978-81-308-0292-3

PUBLICATIONS

The most recent publications reported below from pubmed. Visit Dr. Squarize's pubmed page for the complete list of publications.

Epigenetic Modifications and Head and Neck Cancer: Implications for Tumor Progression and Resistance to Therapy.

Epigenetic Modifications and Head and Neck Cancer: Implications for Tumor Progression and Resistance to Therapy.

Int J Mol Sci. 2017 Jul 12;18(7):

Authors: Castilho RM, Squarize CH, Almeida LO

Abstract
Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer and one of the most aggressive malignancies worldwide. Despite continuous efforts to identify molecular markers for early detection, and to develop efficient treatments, the overall survival and prognosis of HNSCC patients remain poor. Accumulated scientific evidences suggest that epigenetic alterations, including DNA methylation, histone covalent modifications, chromatin remodeling and non-coding RNAs, are frequently involved in oral carcinogenesis, tumor progression, and resistance to therapy. Epigenetic alterations occur in an unsystematic manner or as part of the aberrant transcriptional machinery, which promotes selective advantage to the tumor cells. Epigenetic modifications also contribute to cellular plasticity during tumor progression and to the formation of cancer stem cells (CSCs), a small subset of tumor cells with self-renewal ability. CSCs are involved in the development of intrinsic or acquired therapy resistance, and tumor recurrences or relapse. Therefore, the understanding and characterization of epigenetic modifications associated with head and neck carcinogenesis, and the prospective identification of epigenetic markers associated with CSCs, hold the promise for novel therapeutic strategies to fight tumors. In this review, we focus on the current knowledge on epigenetic modifications observed in HNSCC and emerging Epi-drugs capable of sensitizing HNSCC to therapy.

PMID: 28704968 [PubMed - in process]

Digital Version

NEWS

Squarize Wins Major Award from Robert Wood Johnson Foundation

Dr. Cristiane Squarize, an assistant professor in the Department of Periodontics and Oral Medicine, received the award which is designed to increase the number of faculty from diverse backgrounds who have the potential to reach positions of influence in academic medicine or dentistry, and who will serve as role models and be mentors to students with similar backgrounds. Read the full article

LAB TEAM

Cristiane H. Squarize, DDS, MS, PhD

Principal Investigator
csquariz@umich.edu

Luciana O. Almeida, PhD

Research Fellow, Biologist
lucianao@umich.edu

John M. Le

DDS Candidate, Research Pathways Program
johnmle@umich.edu

Liana Preto Webber, DDS, MS

Visiting Scholar, PhD Candidate
lpretowe@umich.edu

Ana Elizia Mascarenhas, DDS, MS

PhD Candidate

Glaucia Soares, DDS, MS

PhD Candidate

Veronica Yujra DDS, MS

PhD Candidate

Thamara Bezerra DDS, MS

PhD Candidate

Brian Yip

DDS Candidate, Research Pathways Program
brianyip@umich.edu

LAB ALUMNI

Marco Antonio Trevizani Martins, DDS, MS, Ph.D.

Visiting Professor, Laboratory of Epithelial Biology
marcotm@umich.edu

Chiara Zagni, PhD

Research Fellow, Chemist
uchiacch@unict.it

Fernanda Giudice, DDS, MS

Visiting Scholar, Laboratory of Epithelial Biology
fernandagiudice@yahoo.com.br

Carolina Siviero Dillenburg, DDS, MS

Visiting Student, Oral Pathology
carolsd@gmail.com

Manoela Domingues Martins, DDS, MS, PhD

Visiting Professor, Sabbatical, Oral Pathology
manomartins@gmail.com

Camila Matsumoto, PhD

Visiting Scholar, Pharmacist
camilasm.85@gmail.com

Alissa Pullos, DDS

Research Pathways Program
alissa.pullos@uc.edu

Maria José Fernandez, DDS, PhD

Visiting Scholar, Orthodontist
mariajosefernandez_75@hotmail.com

Vivian Petersen Wager, DDS, MS

Visiting Scholar
petersev@umich.edu

CONTACT

Squarize Lab
1011 N. University, Room 6218
Ann Arbor, MI 48109-1078
734-615-3406
csquariz@umich.edu