RESEARCH

The Simmer Hu laboratory studies tooth development, focusing on the human genetics of developmental anomalies of the dentition and using mouse models to understand how proteins encoded by genes function during normal tooth development and how their mutations lead to failures in such process.

The ultimate goal of our research is to apply scientific discoveries toward devising therapeutic measures for human disorders and diseases involving teeth.

The Simmer Hu lab played important parts in the first cloning of cDNA encoding enamelin (Enam), matrix metallowproteinase 20 (Mmp20) and kallikrein 4 (Klk4), and in the initial discoveries that MMP20, ITGB6 and FAM83H defects cause isolated amelogenesis imperfecta and that defects in FAM20A cause Enamel Renal Syndrome. These studies have greatly advanced our understanding of normal tooth development and associated disorders, leading to improvements in their diagnosis, prognosis and intervention.

DIRECTORS

James P. Simmer, DDS, PhD

Professor, Biologic and Materials Sciences/Prosthodontics
University of Michigan School of Dentistry
1210 Eisenhower Place
Ann Arbor, MI 48108
Phone: (734) 975-9318
Fax: (734) 975-9329
jsimmer@umich.edu

Dr. Simmer is Professor in the Department of Biologic and Material Sciences. He received his DDS degree from the University of Michigan School of Dentistry in 1980, and received his PhD in Biochemistry from Wayne State University School of Medicine in 1990. He also did post-doctoral training with Dr. Hal Slavkin, at the Center for Craniofacial Molecular Biology in the University of Southern California School of Dentistry in Los Angeles, California. Before coming to Michigan, Dr. Simmer was an Associate Professor in the Dept. of Pediatric Dentistry at the University of Texas Health Science Center at San Antonio.

Dr. Simmer possesses excellent research and teaching credentials. His research interests are in the area of tooth development, enamel and dentin formation, biochemistry and molecular biology of amelogenins, and hypophosphatasia and amelogenesis imperfecta.

Jan C.C. Hu, BDS, PhD

Samuel D. Harris Collegiate Professor of Dentistry
Director, Oral Health Sciences PhD Program

University of Michigan School of Dentistry
1011 N. University Ave.
Ann Arbor, MI 48109
Phone: (734) 763-6769
Fax: (734) 647-6805
janhu@umich.edu

Dr. Hu completed her Bachelor of Dental Surgery degree from National Taiwan University in 1985. She earned a specialty certificate in pediatric dentistry and a PhD in craniofacial biology (1990) at the University of Southern California, completed a postdoctoral fellowship in craniofacial molecular biology and held the position of clinical assistant professor. In 1993, she joined the Department of Pediatric Dentistry at the University of Texas Health Science Center in San Antonio where she was promoted to the rank of associate professor with tenure in 1999.

Dr. Hu joined the U-M School of Dentistry in 2002 as an associate professor with tenure. In 2005 she was named the director of pediatric dentistry and in 2006 was promoted to full professor. She directs the Oral Health Sciences PhD program since November 2010. Dr. Hu’s research concentrates on tooth development and dental genetics; her clinical research interests focus on pulp biology and therapy.

PUBLICATIONS

Complete list of publications of Dr. James Simmer and Dr. Jan Hu at NCBI.


SELECTED SCIENTIFIC PAPERS

Wang S-H, Hu Y, Yang J, Smith CE, Nunez SM, Richardson AS, Pal S, Samann AC, Hu JC-C, and Simmer JP (2015)
Mol Genet Genomic Med 3:302-19. PMID: 26247047.

Digital Version

Yang J, Wang S-H, Choi M, Reid BM, Hu Y, Lee Y-L, Herzog CR, Kim-Berman H, Lee M, Benke PJ, Kent Lloyd KC, Simmer JP, Hu JC-C (2015)
Mol Genet Genomic Med 3:40-58. PMID: 25629078.

Digital Version

Wang SK, Choi M, Richardson AS, Reid BM, Lin BP, Wang SJ, Kim JW, Simmer JP, Hu JC-C (2014)
Hum Mol Genet 23:2157-63. PMID: 24305999.

Digital Version

Wang SK, Aref P, Hu Y, Milkovich RN, Simmer JP, El-Khateeb M, Daggag H, Baqain ZH, Hu JC (2013)
PLoS Genet 9:e1003302. PMID: 23468644.

Digital Version

Kawasaki K, Hu JC and Simmer JP (2014)
Biol Chem 395:1003-13. PMID: 25153384.

Digital Version

Smith CE, Richardson AS, Hu Y, Bartlett JD, Hu JC, Simmer JP (2011)
J Biol Chem 286:18149-18160. PMID: 21454549.

Digital Version

Kim JW, Lee SK, Lee ZH, Park JC, Lee KE, Lee MH, Park JT, Seo BM, Hu JC, Simmer JP.
Am J Hum Genet 2008 Feb; 82(2): 489-94. PMID: 18252228.

Digital Version

Yamakoshi Y, Lu Y, Hu JC, Kim JW, Iwata T, Kobayashi K, Nagano T, Yamakoshi F, Hu Y, Fukae M, Simmer, JP (2008)
J Biol Chem 283:14835-44. PMID: 18359767.

Digital Version

Kim J-W, Simmer JP, Hart TC, Hart PS, Bartlett JD, Hu JC-C (2005)
J Med Genet 42:271-275. PMID: 15744043.

Digital Version

Mårdh CK, Bäckman B, Holmgren G, Hu JC-C, Simmer JP, Forsman-Semb K (2002)
Hum Mol Genet 11:1069-1074. PMID: 11978766.

Digital Version

Fincham AG, Moradian-Oldak J, Simmer JP (1999)
J Struct Biol 126(3) 270-299. PMID: 10441532.

Digital Version


SELECTED PEDAGOGICAL AND CLINICAL PAPERS

Vieira AR, Lee M, Vairo F, Loguercio Leite JC, Munerato MC, Visioli F, D'Avila SR, Wang SK, Choi M, Simmer JP, Hu JC. (2015)
Oral Surg Oral Med Oral Pathol Oral Radiol 120:e235-9. PMID: 26337219.

Digital Version

Mettlach SM, Zealand CM, Botero TM, Boynton JR, Majewski RF, Hu JCC.
Pediatr Dent 2013;35(3):E87-94. PMID: 23756301.

Digital Version

Chen CF, Hu JC, Bresciani E, Peters M, Estrella MRN
Brazilian Dent Sci 2013, 16(4):7-18. PMID: 23930633.

Digital Version

Majewski RF, da Fonseca MA, DeVries ES, Hu JCC, Murdoch-Kinch CA
J Dent Educ. 2009 Mar;73(3):338-44. PMID: 19289723.

Digital Version

Hu, J, Simmer J, Murdoch-Kinch C, Klausner C, Coplen A, Bleed M, and Johnson L
MedEdPORTAL ; 2009.

Digital Version

Hu J, Beattie M, Murdoch-Kinch C, Coplen A, Bleed M, Johnson L
MedEdPORTAL ; 2009.

Digital Version

LAB TEAM

James P. Simmer

Professor, Biologic and Materials Sciences/Prosthodontics
University of Michigan School of Dentistry
1210 Eisenhower Place
Ann Arbor, MI 48108
Phone: (734) 975-9318
Fax: (734) 975-9329
jsimmer@umich.edu

Jan C.C. Hu

Samuel D. Harris Collegiate Professor of Dentistry
Director, Oral Health Sciences PhD Program

University of Michigan School of Dentistry
1011 N. University Ave.
Ann Arbor, Michigan 48109
Phone: (734) 763-6769
Fax: (734) 647-6805
janhu@umich.edu

Charles E. Smith

Adjunct Research Scientist, Biologic and Materials Sciences
Professor, Department of Anatomy and Cell BiologyFaculty of Medicine

Strathcona Anatomy & Dentistry Building
McGill University
Telephone: (514) 398-4520
Fax: 514-398-5047
cessmith@umich.edu

Yuanyuan Hu, PhD

Research Laboratory Specialist Lead
Biologic and Materials Sciences
University of Michigan School of Dentistry
1210 Eisenhower Place
Ann Arbor, MI 48108
Phone: (734) 975-9326
Fax: (734) 975-9329
yyhu@umich.edu

Chunhua Zeng

Research Lab Technician Lead
Biologic and Materials Sciences
University of Michigan School of Dentistry
1210 Eisenhower Place
Ann Arbor, MI 48108
Phone: (734) 975-9326
Fax: (734) 975-9329
chunhuaz@umich.edu

Lisa Hong Zhang, PhD

Postdoctoral Fellow
Biologic and Materials Sciences
University of Michigan School of Dentistry
1210 Eisenhower Place
Ann Arbor, MI 48108
Phone: (734) 975-9326
Fax: (734) 975-9329
zhanghon@umich.edu

Lorenza A. Donnelly

DDS Class of 2018
University of Michigan School of Dentistry
loriad@umich.edu

Lori graduated with a Bachelor of Science in Cell and Molecular Biology with Highest Distinction and High Honors from the University of Michigan in 2014. Lori’s research concentrates on improving the accuracy of SMRT sequencing of the highly repetitive coding sequence of human dentin sialophosphoprotein and the design of a mouse model containing a human DSPP mutation. Lori is a recipient of the 2015 AADR Student Research Fellowship.

 

Simmer Hu Lab Alumni / Collaborators

ALUMNI AND COLLABORATORS

Yong-Hee Chun, DDS, MS, PhD

Assistant Professor
Department of Periodontics, Department of Cellular and Structural Biology
University of Texas Health Science Center at San Antonio
Phone: 210-567-3520
chuny@uthscsa.edu
Yong-Hee Chun Faculty Profile

Yasuo Yamakoshi, PhD

Professor, Biochemistry
Tsurumi University School of Dentistry
Phone: (045) 580-8374
Fax: (045) 573-9599
yamakoshi-y@tsurumi-u.ac.jp

Amelia S Richardson

DDS class of 2018
University of Michigan School of Dentistry
ramelia@umich.edu

Amelia graduated magna cum laude with a Bachelors of Science in Biology from Eastern Michigan University in 2008. She joined our lab in 2009. Her outstanding contributions in animal management, tissue dissection, immunohistochemistry and various microscopy projects resulted in 17 peer-reviewed publications from 2010-2015.

Shih-Kai Wang, DDS, PhD

Adjunct Assistant Professor
School of Dentistry, National Taiwan University
Residency of Pediatric Dentistry
National Taiwan University Children's Hospital
Oral Health Sciences PhD 2014
University of Michigan School of Dentistry
Phone: 886-905191923
shihkaiw@umich.edu

Jack Jie Yang, DDS, PhD

Clinical Assistant Professor, Pediatric Dentistry
School and Hospital of Stomatology, Peking University
Research focus: Applications of dental stem cell and study of abnormalities of tooth development
denyj78@163.com

Curtis C. Herzog

DDS class of 2020
University of Michigan School of Dentistry
crherzog@umich.edu

Curtis graduated with a Bachelor of Science in Biomolecular Science from the University of Michigan in 2015. As an undergraduate student, he conducted target gene mutational analysis on families with oligodontia and amelogenesis imperfecta. Curtis discovered a novel mutation of SLC24A4, a sodium potassium transporter, resulted in human hypomaturation amelogenesis imperfect.

 

Current Lab Team

CONTACT

Simmer Hu Lab
Dental Research Lab
University of Michigan School of Dentistry
1210 Eisenhower Place
Ann Arbor, MI 48108
Phone: (734) 975-9326
Fax: (734) 975-9329
Email: janhu@umich.edu