McCauley Lab's research interests:
William K. and Mary Anne Najjar Professor
Dean, U-M School of Dentistry
Laurie K. McCauley is the William K. and Mary Anne Najjar Professor and Dean of the School of Dentistry, and Professor in the Department of Pathology at the Medical School at the University of Michigan. Dr. McCauley earned her B.S., D.D.S., M.S. and Ph.D. (Veterinary Pathobiology) all from The Ohio State University. She has had several visiting scientist/professor appointments including the Institut de Genetique et de Biologie Moleculaire et Cellulaire, the École Normale Supérieure de Lyon, and the Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women’s Hospital, Harvard Medical School. Dr. McCauley is a diplomate of the American Board of Periodontology, a fellow in the American Association for the Advancement of Science, a former council member of the American Society for Bone and Mineral Research (ASBMR), former Associate Editor of the Journal of Bone and Mineral Research (JBMR), a Fellow in the American College of Dentists and the International College of Dentists, and also served on the National Institutes of Health, National Advisory Dental & Craniofacial Research Council. For more than twenty years, Dr. McCauley has led an active research program in hormonal controls of bone remodeling, parathyroid hormone anabolic actions in bone, and prostate cancer skeletal metastasis. Among her many recognitions are the inaugural Paula Stern Achievement award from the ASBMR in 2010, a distinguished scientist award from the International Association for Dental Research in 2011, and The Ohio State College of Dentistry Distinguished Alumnus award 2015.
Laurie K. McCauley (Editor), Martha J. Somerman (Editor)
June 2012, Wiley-Blackwell
The most recent 100 publications are reported below via PubMed search.
To see all PubMed results go to this complete listing of publications by Dr. McCauley.
Calcium Sensing Receptor Function Supports Osteoblast Survival and Acts as a Co-Factor in PTH Anabolic Actions in Bone.
J Cell Biochem. 2015 Nov 18;
Authors: Al-Dujaili SA, Koh AJ, Dang M, Mi X, Chang W, Ma PX, McCauley LK
Anabolic actions of PTH in bone involve increased deposition of mineralizing matrix. Regulatory feedback of the process may be important to maintain calcium homeostasis and, in turn, calcium may inform the process. This investigation clarified the role of calcium availability and the calcium sensing receptor (CaSR) in the anabolic actions of PTH. CaSR function promoted osteoblastic cell numbers, with lower cell numbers in post-confluent cultures of primary calvarial cells from Col1-CaSR knock-out (KO) mice, and for calvarial cells from wild-type (WT) mice treated with a calcilytic. Increased apoptosis of calvarial cells with calcilytic treatment suggested CaSR is critical for protection against stage-dependent cell death. Whole and cortical, but not trabecular, bone parameters were significantly lower in Col1-CaSR KO mice versus WT littermates. Intact Col1-CaSR KO mice had lower serum P1NP levels relative to WT. PTH treatment displayed anabolic actions in WT and, to a lesser degree, KO mice, and rescued the lower P1NP levels in KO mice. Furthermore, PTH effects on whole tibiae were inhibited by osteoblast-specific CaSR ablation. Vertebral body implants (vossicles) from untreated Col1-CaSR KO and WT mice had similar bone volumes after 4 weeks of implantation in athymic mice. These findings suggest that trabecular bone formation can occur independently of the CaSR, and that the CaSR plays a collaborative role in the PTH anabolic effects on bone. This article is protected by copyright. All rights reserved.
PMID: 26579618 [PubMed - as supplied by publisher]
Alumni PhD Students
Hen-Li Chen – Associate Professor, National Yang-Ming University, Institute of Oral Biology, Taipei, Taiwan
Burak Demiralp – Associate Professor, Dept. of Periodontology, Hacettepe University, Ankara, Turkey
Tolga Tozum – Associate Professor, Dept. of Periodontology, Hacettepe University, Ankara, Turkey
Abraham Schnieder – Associate Professor, University of Maryland, NIH
Glenda Pettway – Scientist at Kimberly Clark Corporation, Atlanta, GA
Chad Novince – Post-Doc, Department of Oral Health Sciences, Medical University of South Carolina
Fabiana Soki - Radiology Resident, University of Maryland
Kristiann Dougherty - Professor of Psychology-Science, Valencia College, Orlando, FL
Junro Yamashita – Assistant Professor & Assistant Research Scientist, Dept. of Biologic and Materials Sciences, University of Michigan
Jinhui Liao – Post-Doc
Flavia Pirih – Assistant Professor, Director of the Pre-doctoral Program in the Section of Periodontics, Associated Clinical Specialties, School of Dentistry, UCLA
Xin Li – Assistant Professor, Basic Science and Craniofacial Biology, NYU
Sun Wook Cho – Assistant professor, Department of Endocrinology, Seoul National University Hospital, Seoul, Korea
Serkin Park – Assistant Professor, Vanderbilt University
Saja Al-Dujaili - Research Fellow, Pediatric Surgery, University of Michigan Medical School, Ann Arbor, Mi
Jacqueline Jones-Triche - Assistant Professor, University of Alabama at Birmingham and Troy University
Dr. Dale Sweeney – Periodontist, Port Huron, MI
Dr. Alan Padbury – Periodontist, Padbury & Padbury Periodontics, Jackson, MI
Dr. Jill Bashutski - Clinical Assistant Professor, POM, U of M, School of Dentistry, Ann Arbor, MI
Dr. Flavia Pirih – Assistant Professor, Director of the Pre-doctoral Program in the Section of Periodontics, Associated Clinical Specialties, School of Dentistry, UCLA
Dr. Jia Chang - Assistant Professor, Department of Periodontology, University of Florida College of Dentistry
Rahime Nohutcu – Faculty of Dentistry, Dept. of Periodontology, Hacettepe University, Ankara, Turkey
Janice Berry – Retired, University of Michigan Office of Research