MA LAB

ABOUT

Areas of Focus

  1. Bioactive scaffolds for tissue engineering and 3D surface functionalization
  2. Biomimetic Materials: Development of novel synthetic materials inspired by natural materials
  3. Regeneration of 3D functional tissues (bone, cartilage, liver, cardiovascular tissues): understanding polymer-cell interactions and signal and substrate requirements for cell proliferation, differentiation, and tissue regeneration
  4. Controlled Release: Nano/micro-spheres and matrices for the delivery of drugs and biological molecules in a sustained, pulsatile, targeted, or environmentally responsive manner
  5. Phase-separation and Self-assembly: Physical mechanisms and biomedical applications of three-dimensional ordered structure formation, especially at the nanometer scale

DIRECTOR

PETER X MA, PhD, FBSE

Professor, Schools of Dentistry, Engineering, and Medicine

Peter X Ma is the Richard H Kingery Endowed Collegiate Professor of Biologic and Materials Sciences, Biomedical Engineering, Materials Science and Engineering, and Macromolecular Science and Engineering at the University of Michigan. His research is in the areas of biomaterials, biomedical polymers, controlled release, tissue engineering, and regenerative medicine. He pioneers biomimetic scaffold development to design microenvironments for cells and tissue regeneration. He also develops controlled delivery systems for non-viral nucleic acids, peptides, proteins, and small molecules in sustained, pulsatile, and targeted fashions.

Among various recognitions, Dr. Ma received a Whitaker Foundation Biomedical Engineering Young Investigator Award, a DuPont Young Professor Award, a Distinguished Scientist Award (Isaac Schour Memorial Award) from the International Association of Dental Research, and a Clemson Award from the Society for Biomaterials. He was named one of the Top 100 materials scientists in the world by Thomson Reuters. He is an elected Fellow of the American Institute for Medical and Biological Engineering, Fellow of Biomaterials Science and Engineering, Fellow of the Materials Research Society and Fellow of American Association for the Advancement of Science.

PUBLICATIONS

Featured Publications

Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects
2016; Nature Communications; Zhang, X. | Li, Y. | Chen, Y.E. | Chen, J. | Ma, P.X.

Local pulsatile PTH delivery regenerates bone defects via enhanced bone remodeling in a cell-free scaffold
2016; Biomaterials; Dang M. | Koh A.J. | Jin X. | McCauley L.K. | Ma, P.X.

Other Recent Publications

LAB TEAM

Postdoctoral Researcher(s)

DR. KEMAO XIU

Research Specialist

Macromolecular design and synthesis of biodegradable scaffolds for tissue engineering and microgels for drug delivery.


Visiting Scholars

DR. RUONAN DONG

MicroRNAs to induce the differentiation of cardiac progenitor cells for cardiac regeneration.

MINGYANG HEI

PhD Candidate

Construction of thermo-responsive drug delivery system and dual delivery systems for bone tissue engineering.

MEIHUA XIE

PhD Candidate

Development of hydrogels for tissue engineering and novel microgels for drug delivery.

JUN WANG, MD

PhD Candidate

Intervertebral disc and cartilage regeneration.


Doctoral Students

MING DANG

PhD Candidate

Preprogrammed drug delivery device for osteoporosis treatment and bone regeneration, stimuli-responsive hydrogel, and biomimetic approaches in bone regeneration.

YASMINE DOLEYRES

PhD Candidate

Peptide-functionalized particle drug delivery strategies to target HER2+ breast cancer cells and regenerate adipose tissue through eventual minimally invasive techniques using the Ma lab's nanofibrous microsphere cell carrier platform for soft tissue defects.

SAM (RENATO) NAVARRO

PhD Candidate

Sam is developing a Biomimetic scaffold for the regeneration of blood vessels.

KUNAL RAMBHIA

PhD Candidate

Regeneration of critical size bone defects using nanofibrous spongy microspheres developed in the Ma Lab and a dual drug delivery platform.

LAURA SAUNDERS

PhD Pre-Candidate

Polymeric vectors for delivery of nucleotides based on a two-stage system developed in the Ma Lab. Possible applications include delivery of miRNA in therapy for breast cancer and fibrosis.

KELLY WANG

PhD Pre-Candidate

Drop on demand, 3D printing of hydrogels and other biomimetic polymers for tissue regeneration. Possible focus on bone or cartilage regeneration.


Undergraduates

JULIE RIELAND

AMANI STRONG

MIKAYLA DOEPKER

GUADALUPE SALAZAR

ALUMNI AND COLLABORATORS


Current Lab Team

CONTACT

Ma Lab
University of Michigan School of Dentistry
1011 N. University, Room 2211
Ann Arbor, MI 48109
Phone: (734) 764-2209
Email: mapx@umich.edu