KAIGLER LAB

The Kaigler Research Group has special interest in the development of tissue regenerative approaches to regenerate and engineer oral and maxillofacial tissues including: bone, gingiva, and tooth-related structures (periodontal ligament, dentin, dental pulp).  The scope of our work ranges from fundamental studies at the molecular level to human investigations involving clinical trials. A central focus of our work aims to translate our basic research laboratory findings into clinical applications to help treat patients.

CLINICAL STEM CELL THERAPY

Stem cells within the body have the potential to heal and regenerate damaged tissues and organs. We are developing therapies aimed to use these stem cells where needed in order to restore function to tissues which have been lost or compromised due to disease or injury.


Approach for Clinical Transplantation of Bone Marrow Derived Stem Cells


Stem Cell Interfaces with Biomaterials

Stem cell attachment to polymer scaffold prior to clinical transplantation

BONE TISSUE ENGINEERING

For a number of years, many scientists and clinicians have used different methods aimed to restore lost or damaged bone tissue. Following craniofacial bone tissue engineering in our patients using stem cell therapy, we confirm that the regenerated bone is metabolically active and functions like bone.


Following clinical stem cell therapy in a patient, histological analysis and ultra-high resolution 3-dimensional imaging of the engineered tissue confirms viable bone tissue regeneration.


CT scans of the upper jaw (maxilla) following craniofacial stem cell therapy in our patients show 3-dimensional views into the maxillary sinus cavity. The blue area shows the regenerated bone.

ORAL-DERIVED STEM CELL CHARACTERIZATION

Stem cells can be procured from many different parts of the body. Following procurement, they can be multiplied outside of the body in order to be re-introduced to the body in areas of need. Our group is developing techniques for safely procuring stem cells from tissues of the mouth (teeth, bone, gingival tissue) so that these cells can be used to restore tooth and tooth-related tissues lost from diseases of the mouth (gum disease, tooth decay).


Stem Cell Interfaces with Other Cells

Stem cells interact with their environment directly, through contact, or indirectly through their production of growth factors. Our work aims to understand stem cell behavior and how these cells interact with other cells to influence their behavior. Additionally, we are studying how different stem cells respond to materials which can be used to deliver them.

Periodontal ligament stem cells and mesenchymal stem cells stimulating endothelial cells to form vessels.

Dental Pulp Tissue Regeneration

An in vitro scratch assay showing cell to cell interactions of Dental Pulp Stem Cell (DPSC) migration in vitro.

AWARDS

Sigmund Socransky Young Investigator Award

American Association of Dental Research, 2013

Graduate Student Research Forum Winner

Midwest Society for Periodontology, 2013

Suzanne Mason, awarded First Place Investigator Award for her project “Standardized Approach for Isolating Mesenchymal Stem Cells from Alveolar Bone”

Grand Prize Research Winner

University of Michigan School of Dentistry Annual Research Day, 2013

Emily Eubanks, awarded Grand Prize for her project “Storage of 3rd Molars for Stem Cell Isolation and Expansion in Animal-Sera Free Media”

Basic Science and Research Winner

University of Michigan School of Dentistry Annual Research Day, 2016

Elizabeth Hatfield, awarded 3rd Place Winner for “Effects of long-term expansion on senescence and differentiation of dental pulp stem cells (DPSCs)”

Basic Science Research Award, 3rd place winner, Elizabeth Hatfield, University of Michigan School of Dentistry Annual Research Day, 2016

Sigurd Ramfjord Symposium, 1st place winner of Clinical Science award, Angeliki Polymeri, University of Michigan School of Dentistry, 2016

Basic Science Research Award, Grand Prize Research winner, Andrei Taut, University of Michigan School of Dentistry Annual Research Day, 2015, D.D.S.

Sigurd Ramfjord Symposium, 2nd place winner, Research Poster Presentation, Alejandro Lanis, University of Michigan School of Dentistry, 2014

Basic Science Research Award, 1st place winner, Emily Eubanks, University of Michigan School of Dentistry Annual Research Day, 2014

Henry M. Goldman Award for Best Research Project, Giorgio Pagni, Italian Society of Periodontology, 15th International Congress 2011

Journal of Dental Research Gies Award
Most Outstanding Manuscript in Biomaterials and Biotechnology Research, 2006

Abram and Sylvia Chasens Teaching and Research Award
American Academy Periodontology, 2006

Journal of Dental Research Gies Award
Most Outstanding Manuscript Biomaterials and Biotechnology Research, 2004

Most Outstanding Manuscript Award
Journal of Dental Education, 2001

PUBLICATIONS

The most recent publications are reported below via Scopus search.

TEAM

Research Team Leader

DARNELL KAIGLER, JR, DDS, MS, PhD

Associate Professor
University of Michigan School of Dentistry
Department of Periodontics and Oral Medicine
College of Engineering
Department of Biomedical Engineering
1011 N. University Ave
Ann Arbor, MI 48109-1078
734-615-4023 | Fax 734-763-5023
dkaigler@umich.edu


Research Team Members

SUE TARLE

Sr. Research Specialist
starle@umich.edu

CHEN CAO

Research Fellow
cheery@umich.edu

TRANG NGUYEN

International Team for Implantology (ITI) Scholar
nvnt@umich.edu

MAGGIE ANDERSON

DDS, MS Orthodontics Resident
mtander@umich.edu

BART MASKA

DDS, MS Periodontics Resident
bmaska@umich.edu

TYLER GUINN

DDS Student
tjguinn@umich.edu

Kelsie Pittel

DDS Student
kelsiep@umich.edu

MALIKA MALIK

DDS Student
mamalik@umich.edu

ALUMNI

ANGELIKI POLYMERI

International Team for Implantology (ITI) Scholar
polyan@umich.edu

ALEJANDRO LANIS

Visiting ITI Scholar
alejandrolanis@yahoo.com

RICK MIRON

International Team for Implantology (ITI) Scholar
rmiron@umich.edu

FENG WANG

ITI Scholar
diana_wangfeng@hotmail.com

GIORGIO PAGNI

DDS MS Periodontal Resident
giorgio.pagni@gmail.com

DUOHONG ZOU

Visiting Professor
zouduohongyy@126.com

GUSTAVO AVILA

Research Associate
gustavo-avila@uiowa.edu

SHAMIMA YEASMIN

Research Fellow
yeasminshamima@yahoo.com

SUZANNE MASON

DDS MS Periodontics Resident
suemason7@gmail.com

ARCHANA RAJAN

DDS MS Orthodontics Resident
arch_rjn@yahoo.com

MONA BAJESTAN

DDS MS Orthodontics Resident
bajestan@umich.edu

ELIZABETH HATFIELD

DDS Student
lizhat@umich.edu

EMILY EUBANKS

DDS Candidate
emeubank@umich.edu

DAVID LI

DDS Candidate
davidmli@umich.edu

PARMINDER DULAY

DDS Candidate
pdulay@umich.edu

WILL OSIBIN

DDS Candidate
osibinwi@umich.edu

YADIEL KINFU

Undergraduate Student

EVAN D'SILVA

Undergraduate Student
edsilva@umich.edu

>

COLLABORATORS

SHARON ARONOVICH

University of Michigan
Faculty Profile

DAVID J. MOONEY

Harvard University
Mooney Lab

SEAN P. EDWARDS

University of Michigan
Faculty Profile

ANDREW PUTNAM

University of Michigan
Faculty Profile

WILLIAM GIANNOBILE

University of Michigan
Giannobile Lab

SONGTAO SHI

University of Pennsylvania
Faculty Profile

FUN

Kaigler Research Group “In Action”

FUN

Kaigler Research Group when NOT “In Action”

CONTACT

DARNELL KAIGLER, JR, DDS, MS, PhD

University of Michigan School of Dentistry
Department of Periodontics and Oral Medicine
Room 3305
1011 N. University Ave
Ann Arbor, MI 48109-1078
734-615-4023
dkaigler@umich.edu

SUE TARLÉ

Lab Manager
University of Michigan School of Dentistry
Department of Periodontics and Oral Medicine
Room 3310G
1011 N. University Ave
Ann Arbor, MI 48109-1078
734-615-5302
starle@umich.edu