The University of Michigan School of Dentistry
The Hatch laboratory studies craniofacial skeletal development, using mouse models for genetic and epigenetic study, identification and phenotyping of developmental changes and cell biologic defects underlying craniosynostosis and cranial base defects.
We strive to delineate molecular defects in essential developmental pathways to ultimately provide improved prognostic indicators and medical treatment options for patient with craniofacial abnormalities.
[email protected] | (734) 647-6567
Dr. Hatch completed her Doctor of Medicine in Dentistry from Harvard University in 1999. She earned an orthodontic clinical specialty certificate (2002) and a PhD in Molecular and Cell Biology (2005) from the University of Washington in Seattle. She completed a postdoctoral fellowship as a trainee on the institutional Tissue Engineering and Regeneration (TEAM) T32 training grant at the University of Michigan, School of Dentistry. She was hired as an Assistant Professor of Dentistry at the University of Michigan in 2008 and became a tenured Associate Professor of Dentistry in 2015.
Dr. Hatch became the Lysle E. Johnston, Jr. Collegiate Professor of Orthodontics and Chair of the Department of Orthodontics and Pediatric Dentistry in 2016. Dr. Hatch’s research concentrates on craniofacial skeletal development with a goal of identifying primary mediators and modifiers of abnormal craniofacial skeletal development. She also works to establish biologic mediators for control of orthodontic tooth movement and retention.
| 1990 | BS, Psychology, Tufts University, Medford MA |
| 1999 | DMD, Harvard School of Dental Medicine, Boston MA |
| 2002 | Orthodontic Certificate, University of Washington, Seattle WA |
| 2005 | PhD, Molecular and Cell Biology, University of Washington, Seattle WA |
| 2003-2004 | Teaching Assistant, Biochemistry, University of Washington, Seattle, WA |
| 2005-2008 | Research Fellow, Tissue Engineering and Regeneration T32, School of Dentistry, University of Michigan, Ann Arbor, MI |
| 2008-2015 | Assistant Professor, Department of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, MI |
| 2015-2019 | Research Director, Division of Orthodontics, School of Dentistry, University of Michigan, Ann Arbor, MI |
| 2015- | Lysle E Johnston, Jr. Collegiate Professor of Orthodontics and Associate Professor of Dentistry |
| 2016- | Chair, Department of Orthodontics and Pediatric Dentistry, University of Michigan, Ann Arbor, MI |
Identifying Modifiers and Primary Mediators of Phenotype Severity in Craniosynostosis.
Neural Crest Specific Knockout of TNAP to Establish TNAP as Essential Regulator of Craniofacial Stem Cells in Development.
Potential Rescue of Craniofacial Abnormalities by Arqule in the Mouse Model of Crouzon Syndrome.
Determine Mechanisms by which FGFR2 Mediates Craniosynostosis in Alpl-/- Mouse Model of Hypophosphatasia.
Paraxial Mesoderm vs. Cranial Neural Crest Cell Effects of Craniosynostosis associated FGFR2C342Y Mutation
Alpl-/- Mouse Model of Hypophosphatasia
Does Elimination of Enpp1 Rescue Craniofacial Bone Abnormalites in Alpl-/- Mouse Model of Hypophosphatasia?
FGF2 Treatment for Rescue of Bone Mineralization in Alpl-/- Mouse Model of Hypophosphatasia.
Investigating Inflammatory Mediators in Microspheres to Control Tooth Movement.
Paraxial Mesoderm vs. Cranial Neural Crest Cell Effects of Craniosynostosis associated FGFR2C342Y Mutation