Our laboratory is exploring the potential of novel methods of growth factor delivery such as gene therapy to stimulate periodontal tissue repair.

William Giannobile, DDS, MS, DMSc


The Giannobile laboratory explores the potential of novel methods of growth factor delivery such as gene therapy to stimulate periodontal tissue repair. In addition, the lab is involved in clinical research to develop predictive markers of periodontal and peri-implant bone loss.


William V. Giannobile, DDS, MS, DMSc
Najjar Endowed Professor of Dentistry and Biomedical Engineering
Department of Periodontics and Oral Medicine
University of Michigan School of Dentistry
1011 N. University Ave, Rm #3397
Ann Arbor, MI 48109-1078
734-763-2105 wgiannob@umich.edu

Dr. Giannobile is the Najjar Endowed Professor of Dentistry and Biomedical Engineering and Chair of the Department of Periodontics and Oral Medicine at the School of Dentistry. He received his DDS and an MS in Oral Biology from the University of Missouri. He later received his certificate in Periodontology and Doctor of Medical Science in Oral Biology from Harvard University. He subsequently completed postdoctoral training in Molecular Biology at the Dana Farber Cancer Institute and Harvard Medical School.

Dr. Giannobile previously served as a faculty member at Harvard and Forsyth Institute in Boston. He has published and lectured extensively in the fields of Regenerative Medicine, Tissue Engineering, and Salivary Diagnostics as it relates to periodontal and peri-implant reconstruction.

Dr. Giannobile is an Editor-in-Chief of the Journal of Dental Research and is on the editorial boards of multiple journals. He is a fellow of the American College of Dentists and a Diplomate of the American Board of Periodontology. Dr. Giannobile currently serves as president of the American Academy of Periodontology Foundation.

Dr. Giannobile also serves as a consultant to the National Institutes of Health. To read more about Dr. Giannobile as an NIDCR investigator, please visit the NIDCR website for an article on the future impact of research on periodontal disease.


The most recent 50 publications are reported below via PubMed search.

To see all PubMed results go to this complete listing of publications by Dr. Giannobile.

Protein biomarkers and microbial profiles in peri-implantitis.

Related Articles

Protein biomarkers and microbial profiles in peri-implantitis.

Clin Oral Implants Res. 2015 Oct 1;

Authors: Wang HL, Garaicoa-Pazmino C, Collins A, Ong HS, Chudri R, Giannobile WV

OBJECTIVES: The aim of the present investigation was to determine the profile of peri-implant crevicular fluid (PICF) biomarkers combined with microbial profiles from implants with healthy peri-implant tissues and peri-implantitis to assess real-time disease activity.
MATERIAL AND METHODS: Sixty-eight patients were included in this cross-sectional study. They were divided into two groups: 34 patients with at least one healthy implant (control) and 34 with at least one peri-implantitis affected implant (test). Total DNA content and qPCR analysis for periodontal bacteria obtained from subgingival plaque samples (Aggregatibacter actinomycetemcomitans, Prevotella intermedia, Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola) and a PICF analysis for IL-1β, VEGF, MMP-8, TIMP-2, and OPG were performed. The individual and combined diagnostic ability of each biomarker for peri-implantitis and target bacterial species were analyzed.
RESULTS: The mean concentration of IL-1β (44.6 vs. 135.8 pg/ml; P < 0.001), TIMP-2 (5488.3 vs. 9771.8 pg/ml; P = 0.001), VEGF (59.1 vs. 129.0 pg/ml; P = 0.012), and OPG (66.5 vs. 111.7 pg/ml; P = 0.050) was increased in the peri-implantitis patients. The mean expression of MMP-8 (6029.2 vs. 5943.1 pg/ml; P = 0.454) and did not reveal a meaningful difference among groups. Total bacterial DNA of selected microorganisms was associated with a threefold or greater increase in peri-implantitis although no statistical significant difference. The ability to diagnose diseased sites was enhanced by T. denticola combined with IL-1β, VEGF, and TIMP-2 PICF levels.
CONCLUSION: The present data suggest that the increased levels of the selected PICF-derived biomarkers of periodontal tissue inflammation, matrix degradation/regulation, and alveolar bone turnover/resorption combined with site-specific microbial profiles may be associated with peri-implantitis and could have potential as predictors of peri-implant diseases.

PMID: 26424287 [PubMed - as supplied by publisher]

Digital Version

News & Media

Dr. Giannobile helps pioneer new approach to dental care: M-Dentistry News

DentNEWS: Dr. Giannobile named new JDR editor-in-chief

Gene therapy to treat gum disease: U-M News Service

The future of periodontology: An interview with Dr. William Giannobile and Dr. Pamela Robey

Growth rate of replacement blood vessels, tissues: U-M News Service

Gene therapy promising for growing tooth-supporting bone: U-M News Service

Current Members

William V. Giannobile, DDS, DMSc

Najjar Endowed Professor of Dentistry and Biomedical Engineering
Chair, Department of Periodontics and Oral Medicine


Jim Sugai

Research Laboratory Specialist Senior jsugai@umich.edu

Sophia Pilipchuk

PhD Graduate Student

Laura Kruger

Undergraduate Student

Dr. Lena Larsson

Visiting Scholar

Ana Claudia de Araujo Pires

Postdoctoral Fellow

Yizu Jiao

Postdoctoral Fellow

Jie Hao

Research Scholar

Alexandra Plonka

Periodontics MS student

Alberto Monje

Periodontics MS student

Nolan Kavanagh

Undergraduate student


Dr. Salvatore Batia

Dr. Po Chun Chang

Dr. Jong-Hyuk Chung
Kyung Hee University, Seoul, Korea

Dr. Joni Cirelli

Dr. Roberto Farina

Dr. Lukas Furhauser

Dr. Reinhard Gruber

Qiming Jin

Dr. Zhao Lin

Julie Marchesan

Dr. Andrea Ottonello

Dr. Chan Ho Park

Dr. Gaia Pelligrini

Dr. Christoph Ramsier

Dr. Stefan Schroeckmair, Bernhard Gottlieb University Clinic of Dentistry, Vienna, Austria

Seung-Yun Shin 

Dr. Mario Taba, Jr.

Dr. Valeria Tedeschi

Dr. Kemal Ustun

Dr. Christian Wehner, Bernhard Gottlieb University Clinic of Dentistry, Vienna, Austria

Dr. Andreas Weisbauer

Dr. Yang-Jo Seol


Giannobile Lab

University of Michigan School of Dentistry
Department of Periodontics & Oral Medicine
Room 3310-O Dental Building
1011 N. University Avenue
Ann Arbor, MI 48109

Phone: 734-615-2467
Fax: 734-763-5503