Our laboratory is exploring the potential of novel methods of growth factor delivery such as gene therapy to stimulate periodontal tissue repair.

William Giannobile, DDS, MS, DMSc

About

The Giannobile laboratory explores the potential of novel methods of growth factor delivery such as gene therapy to stimulate periodontal tissue repair. In addition, the lab is involved in clinical research to develop predictive markers of periodontal and peri-implant bone loss.


Director

William V. Giannobile, DDS, MS, DMSc
Najjar Endowed Professor of Dentistry and Biomedical Engineering
Department of Periodontics and Oral Medicine
University of Michigan School of Dentistry
1011 N. University Ave, Rm #3397
Ann Arbor, MI 48109-1078
734-763-2105 wgiannob@umich.edu

Dr. Giannobile is the Najjar Endowed Professor of Dentistry and Biomedical Engineering and Chair of the Department of Periodontics and Oral Medicine at the School of Dentistry. He received his DDS and an MS in Oral Biology from the University of Missouri. He later received his certificate in Periodontology and Doctor of Medical Science in Oral Biology from Harvard University. He subsequently completed postdoctoral training in Molecular Biology at the Dana Farber Cancer Institute and Harvard Medical School.

Dr. Giannobile previously served as a faculty member at Harvard and Forsyth Institute in Boston. He has published and lectured extensively in the fields of Regenerative Medicine, Tissue Engineering, and Salivary Diagnostics as it relates to periodontal and peri-implant reconstruction.

Dr. Giannobile is an Editor-in-Chief of the Journal of Dental Research and is on the editorial boards of multiple journals. He is a fellow of the American College of Dentists and a Diplomate of the American Board of Periodontology. Dr. Giannobile currently serves as president of the American Academy of Periodontology Foundation.

Dr. Giannobile also serves as a consultant to the National Institutes of Health. To read more about Dr. Giannobile as an NIDCR investigator, please visit the NIDCR website for an article on the future impact of research on periodontal disease.

Publications

The most recent 100 publications are reported below via PubMed search.

To see all PubMed results go to this complete listing of publications by Dr. Giannobile.

TLR4, NOD1 and NOD2 Mediate Immune Recognition of Putative Newly-Identified Periodontal Pathogens.

Related Articles

TLR4, NOD1 and NOD2 Mediate Immune Recognition of Putative Newly-Identified Periodontal Pathogens.

Mol Oral Microbiol. 2015 Jul 14;

Authors: Marchesan J, Jiao Y, Schaff RA, Hao J, Morelli T, Kinney JS, Gerow E, Sheridan R, Rodrigues V, Paster BJ, Inohara N, Giannobile WV

Abstract
Periodontitis is a polymicrobial inflammatory disease that results from the interaction between the oral microbiota and the host immunity. While the innate immune response is important for disease initiation and progression, the innate immune receptors that recognize both classical and putative periodontal pathogens that elicit an immune response have not been elucidated. By using the Human Oral Microbe Identification Microarray (HOMIM), we identified multiple predominant oral bacterial species in human plaque biofilm that strongly associate with severe periodontitis. Ten of the identified species were evaluated in greater depth, 6 being classical pathogens and 4 putative novel pathogens. Using human peripheral blood monocytes (HPBM) and murine bone marrow-derived macrophages (BMDM) from wild-type (WT) and toll-like receptor (TLR)-specific and MyD88 knockouts (KOs), we demonstrated that heat-killed Campylobacter concisus, Campylobacter rectus, Selenomonas infelix, Porphyromonas endodontalis, Porphyromonas gingivalis, and Tannerella forsythia mediate high immunostimulatory activity. C. concisus, C. rectus, and S. infelix exhibited robust TLR4 stimulatory activity. Studies using mesothelial cells from WT and NOD1-specific KOs and NOD2-expressing human embryonic kidney (HEK) cells demonstrated that Eubacterium saphenum, Eubacterium nodatum and Filifactor alocis exhibit robust NOD1 stimulatory activity, and that Porphyromonas endodontalis and Parvimonas micra have the highest NOD2-stimulatory activity. These studies allowed us to provide important evidence on newly-identified putative pathogens in periodontal disease pathogenesis showing that these bacteria exhibit different immunostimulatory activity via TLR4, NOD1, and NOD2 (Clinicaltrials. gov NCT01154855). This article is protected by copyright. All rights reserved.

PMID: 26177212 [PubMed - as supplied by publisher]

Digital Version

News & Media

DentNEWS: Dr. Giannobile named new JDR editor-in-chief

Gene therapy to treat gum disease: U-M News Service

The future of periodontology: An interview with Dr. William Giannobile and Dr. Pamela Robey

Growth rate of replacement blood vessels, tissues: U-M News Service

Gene therapy promising for growing tooth-supporting bone: U-M News Service

Current Members

William V. Giannobile, DDS, DMSc

Najjar Endowed Professor of Dentistry and Biomedical Engineering
Chair, Department of Periodontics and Oral Medicine

wgiannob@umich.edu

Jim Sugai

Research Laboratory Specialist Senior jsugai@umich.edu

Sophia Pilipchuk

PhD Graduate Student
spilipch@umich.edu

Laura Kruger

Undergraduate Student
krulaura@umich.edu

Dr. Lena Larsson

Visiting Scholar
mlarsson@umich.edu

Ana Claudia de Araujo Pires

Postdoctoral Fellow
anaclaud@umich.edu

Yizu Jiao

Postdoctoral Fellow
yizujiao@umich.edu

Jie Hao

Research Scholar
hjie@umich.edu

Alexandra Plonka

Periodontics MS student
aplonka@umich.edu

Alberto Monje

Periodontics MS student
amonjec@umich.edu

Nolan Kavanagh

Undergraduate student
nolankav@umich.edu

Alumni

Dr. Salvatore Batia
salvomarioclaudio@yahoo.it

Dr. Po Chun Chang
changpc@ntu.edu.tw

Dr. Jong-Hyuk Chung
Kyung Hee University, Seoul, Korea

Dr. Joni Cirelli
cirelli@foar.unesp.br

Dr. Roberto Farina
roberto.farina@unife.it

Dr. Lukas Furhauser
lukas.fuerhauser@gmx.at

Dr. Reinhard Gruber
reinhard.gruber@meduniwien.ac.at

Qiming Jin
jinqm@umich.edu

Dr. Zhao Lin
zlin@vcu.edu

Julie Marchesan
julmarch@umich.edu

Dr. Andrea Ottonello
andrea8nello@gmail.com

Dr. Chan Ho Park
chanho@umich.edu

Dr. Gaia Pelligrini
gaiapellegrini.perio@gmail.com

Dr. Christoph Ramsier
christoph.ramseier@zmk.unibe.ch

Dr. Stefan Schroeckmair, Bernhard Gottlieb University Clinic of Dentistry, Vienna, Austria

Seung-Yun Shin 
ssyislet@khu.ac.kr

Dr. Mario Taba, Jr.
mtaba@forp.usp.br

Dr. Valeria Tedeschi
valeriapontelli@forp.usp.br

Dr. Kemal Ustun
k_ustun@yahoo.com

Dr. Christian Wehner, Bernhard Gottlieb University Clinic of Dentistry, Vienna, Austria

Dr. Andreas Weisbauer
andreasweisbauer@hotmail.com

Dr. Yang-Jo Seol
yjseol@snu.ac.kr

Contact

Giannobile Lab

University of Michigan School of Dentistry
Department of Periodontics & Oral Medicine
Room 3310-O Dental Building
1011 N. University Avenue
Ann Arbor, MI 48109

Phone: 734-615-2467
Fax: 734-763-5503