Our laboratory is exploring the potential of novel methods of growth factor delivery such as gene therapy to stimulate periodontal tissue repair.

William Giannobile, DDS, MS, DMSc

About

The Giannobile laboratory explores the potential of novel methods of growth factor delivery such as gene therapy to stimulate periodontal tissue repair. In addition, the lab is involved in clinical research to develop predictive markers of periodontal and peri-implant bone loss.


Director

William V. Giannobile, DDS, MS, DMSc
Najjar Endowed Professor of Dentistry and Biomedical Engineering
Department of Periodontics and Oral Medicine
University of Michigan School of Dentistry
1011 N. University Ave, Rm #3397
Ann Arbor, MI 48109-1078
734-763-2105 wgiannob@umich.edu

Dr. Giannobile is the Najjar Endowed Professor of Dentistry and Biomedical Engineering and Chair of the Department of Periodontics and Oral Medicine at the School of Dentistry. He received his DDS and an MS in Oral Biology from the University of Missouri. He later received his certificate in Periodontology and Doctor of Medical Science in Oral Biology from Harvard University. He subsequently completed postdoctoral training in Molecular Biology at the Dana Farber Cancer Institute and Harvard Medical School.

Dr. Giannobile previously served as a faculty member at Harvard and Forsyth Institute in Boston. He has published and lectured extensively in the fields of Regenerative Medicine, Tissue Engineering, and Salivary Diagnostics as it relates to periodontal and peri-implant reconstruction.

Dr. Giannobile is an Editor-in-Chief of the Journal of Dental Research and is on the editorial boards of multiple journals. He is a fellow of the American College of Dentists and a Diplomate of the American Board of Periodontology. Dr. Giannobile currently serves as president of the American Academy of Periodontology Foundation.

Dr. Giannobile also serves as a consultant to the National Institutes of Health. To read more about Dr. Giannobile as an NIDCR investigator, please visit the NIDCR website for an article on the future impact of research on periodontal disease.

Publications

The most recent 20 publications are reported below via PubMed search.

To see all PubMed results go to this complete listing of publications by Dr. Giannobile.

Integration of 3D Printed and Micropatterned Polycaprolactone Scaffolds for Guidance of Oriented Collagenous Tissue Formation In Vivo.

Integration of 3D Printed and Micropatterned Polycaprolactone Scaffolds for Guidance of Oriented Collagenous Tissue Formation In Vivo.

Adv Healthc Mater. 2016 Jan 28;

Authors: Pilipchuk SP, Monje A, Jiao Y, Hao J, Kruger L, Flanagan CL, Hollister SJ, Giannobile WV

Abstract
Scaffold design incorporating multiscale cues for clinically relevant, aligned tissue regeneration has potential to improve structural and functional integrity of multitissue interfaces. The objective of this preclinical study is to develop poly(ε-caprolactone) (PCL) scaffolds with mesoscale and microscale architectural cues specific to human ligament progenitor cells and assess their ability to form aligned bone-ligament-cementum complexes in vivo. PCL scaffolds are designed to integrate a 3D printed bone region with a micropatterned PCL thin film consisting of grooved pillars. The patterned film region is seeded with human ligament cells, fibroblasts transduced with bone morphogenetic protein-7 genes seeded within the bone region, and a tooth dentin segment positioned on the ligament region prior to subcutaneous implantation into a murine model. Results indicate increased tissue alignment in vivo using micropatterned PCL films, compared to random-porous PCL. At week 6, 30 μm groove depth significantly enhances oriented collagen fiber thickness, overall cell alignment, and nuclear elongation relative to 10 μm groove depth. This study demonstrates for the first time that scaffolds with combined hierarchical mesoscale and microscale features can align cells in vivo for oral tissue repair with potential for improving the regenerative response of other bone-ligament complexes.

PMID: 26820240 [PubMed - as supplied by publisher]

Digital Version

Effects of Triclosan on Host Response and Microbial Biomarkers during Experimental Gingivitis.

Effects of Triclosan on Host Response and Microbial Biomarkers during Experimental Gingivitis.

J Clin Periodontol. 2016 Jan 28;

Authors: Pancer BA, Kott D, Sugai JV, Panagakos FS, Braun TM, Teles RP, Giannobile WV, Kinney JS

Abstract
AIM: This exploratory randomized, controlled clinical trial sought to evaluate anti-inflammatory and -microbial effects of triclosan during experimental gingivitis as assessed by host response biomarkers and biofilm microbial pathogens.
MATERIALS AND METHODS: Thirty participants were randomized to triclosan or control dentifrice groups who ceased homecare for 21 days in an experimental gingivitis (EG) protocol. Plaque and gingival indices and saliva, plaque, and gingival crevicular fluid (GCF) were assessed/collected at days 0, 14, 21 and 35. Levels and proportions of 40 bacterial species from plaque samples were determined using checkerboard DNA-DNA hybridization. Ten biomarkers associated with inflammation, matrix degradation, and host protection were measured from GCF and saliva and analyzed using a multiplex array. Participants were stratified as 'high' or 'low' responders based on gingival index and GCF biomarkers and bacterial biofilm were combined to generate receiver operating characteristic curves and predict gingivitis susceptibility.
RESULTS: No differences in mean PI and GI values were observed between groups and non-significant trends of reduction of host response biomarkers with triclosan treatment. Triclosan significantly reduced levels of A. actinomycetemcomitans and P. gingivalis during induction of gingivitis.
CONCLUSIONS: Triclosan reduced microbial levels during gingivitis development (ClinicalTrials. gov NCT01799226). This article is protected by copyright. All rights reserved.

PMID: 26820239 [PubMed - as supplied by publisher]

Digital Version

News & Media

Dr. Giannobile helps pioneer new approach to dental care: M-Dentistry News

DentNEWS: Dr. Giannobile named new JDR editor-in-chief

Gene therapy to treat gum disease: U-M News Service

The future of periodontology: An interview with Dr. William Giannobile and Dr. Pamela Robey

Growth rate of replacement blood vessels, tissues: U-M News Service

Gene therapy promising for growing tooth-supporting bone: U-M News Service

Current Members

William V. Giannobile, DDS, DMSc

Najjar Endowed Professor of Dentistry and Biomedical Engineering
Chair, Department of Periodontics and Oral Medicine

wgiannob@umich.edu

Jim Sugai

Research Laboratory Specialist Senior jsugai@umich.edu

Sophia Pilipchuk

PhD Graduate Student
spilipch@umich.edu

Laura Kruger

Research Technician
krulaura@umich.edu

Dr. Lena Larsson

Visiting Scholar
mlarsson@umich.edu

Ning Yu

Postdoctoral Fellow
niyu@umich.edu

Jie Hao

Research Scholar
hjie@umich.edu

Angeliki Polymeri

ITI Scholar
polyan@umich.edu

Alexandra Plonka

Periodontics MS student
aplonka@umich.edu

Alberto Monje

Periodontics MS student
amonjec@umich.edu

Erin Shan Huey Yu

Periodontics MS student
shanhyu@umich.edu

Nolan Kavanagh

Undergraduate student
nolankav@umich.edu

Jeff CW Wang

Clinical Assistant Professor
jeffwa@umich.edu
 

Alumni

Dr. Salvatore Batia
salvomarioclaudio@yahoo.it

Dr. Po Chun Chang
changpc@ntu.edu.tw

Dr. Jong-Hyuk Chung
Kyung Hee University, Seoul, Korea

Dr. Joni Cirelli
cirelli@foar.unesp.br

Dr. Roberto Farina
roberto.farina@unife.it

Dr. Lukas Furhauser
lukas.fuerhauser@gmx.at

Dr. Reinhard Gruber
reinhard.gruber@meduniwien.ac.at

Qiming Jin
jinqm@umich.edu

Dr. Zhao Lin
zlin@vcu.edu

Julie Marchesan
julmarch@umich.edu

Dr. Andrea Ottonello
andrea8nello@gmail.com

Dr. Chan Ho Park
chanho@umich.edu

Dr. Gaia Pelligrini
gaiapellegrini.perio@gmail.com

Dr. Christoph Ramsier
christoph.ramseier@zmk.unibe.ch

Dr. Stefan Schroeckmair, Bernhard Gottlieb University Clinic of Dentistry, Vienna, Austria

Seung-Yun Shin 
ssyislet@khu.ac.kr

Dr. Mario Taba, Jr.
mtaba@forp.usp.br

Dr. Valeria Tedeschi
valeriapontelli@forp.usp.br

Dr. Kemal Ustun
k_ustun@yahoo.com

Dr. Christian Wehner, Bernhard Gottlieb University Clinic of Dentistry, Vienna, Austria

Dr. Andreas Weisbauer
andreasweisbauer@hotmail.com

Dr. Yang-Jo Seol
yjseol@snu.ac.kr

Contact

Giannobile Lab

University of Michigan School of Dentistry
Department of Periodontics & Oral Medicine
Room 3310-O Dental Building
1011 N. University Avenue
Ann Arbor, MI 48109

Phone: 734-615-2467
Fax: 734-763-5503