Our laboratory focus on the understanding of the “histone code” in the context of disease progression (e.g., Periodontal Disease) and cancer biology. We explore the role of histone acetylation and chromatin remodeling in the control of epithelial functions including healing, maintenance of epithelial homeostasis and stem cell function. We also explore the epigenetic-driven mechanisms involved in tumor resistance to ionizing radiation and chemotherapy and focus on the use of “epi-drugs” to counteract cancer-driven histone modifications.
|2003-2010||Post-Doctoral Fellowship, National Institutes of Health (NIDCR)|
|2001-2003||PhD University of Sao Paulo, Brazil|
|1999-2000||MSc University of Sao Paulo, Brazil|
|1999||Certificate in Oral Pathology, Sao Leopoldo Mandic, Brazil|
|1992-1995||DDS Pontific Catholic University of Campinas, Campinas, Brazil|
|2010 - present||Assistant Professor
University of Michigan
School of Dentistry
Division of Oral Pathology/Medicine/Radiology
Department of Periodontics and Oral Medicine
Ann Arbor, MI, USA
|Certificates and Licenses|
|1995||Brazilian Dental License - National Council of Dentistry, Brazil Sao Paulo State Dental License (CROSP)|
|1999||Certificate in Oral Pathology - Advanced Dental Education Sao Leopoldo Mandic, Sao Paulo, Brazil|
|2014||State of Michigan Clinical Academic Limited License|
|2016||Journal of Dental Research|
The most recent publications reported below from pubmed. Visit Dr. Castilho's pubmed page for the complete list of publications.
When epigenetics meets bioengineering-A material characteristics and surface topography perspective.
J Biomed Mater Res B Appl Biomater. 2017 Jul 25;:
Authors: Larsson L, Pilipchuk SP, Giannobile WV, Castilho RM
The field of tissue engineering and regenerative medicine (TE/RM) involves regeneration of tissues and organs using implantable biomaterials. The term epigenetics refers to changes in gene expression that are not encoded in the DNA sequence, leading to remodeling of the chromatin and activation or inactivation of gene expression. Recently, studies have demonstrated that these modifications are influenced not only by biological cues but also by mechanical and topographical signals. This review highlights the current knowledge on emerging approaches in TE/RM with a focus on the effect of materials and topography on the epigenetic expression pattern in cells with potential impacts on modulating regenerative biology. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2017.
PMID: 28741893 [PubMed - as supplied by publisher]
Cancer Biology – Salivary Gland Tumors
Cancer Biology – Head and Neck Squamous Cell Carcinoma (HNSCC)
Epithelial Biology – Periodontal Disease
Epithelial Biology – Titanium Toxicity
Epithelial Biology – Wound Healing