Laboratory of Epithelial Biology

ABOUT

Research Interests

Our laboratory focus on the understanding of the “histone code” in the context of disease progression (e.g., Periodontal Disease) and cancer biology. We explore the role of histone acetylation and chromatin remodeling in the control of epithelial functions including healing, maintenance of epithelial homeostasis and stem cell function. We also explore the epigenetic-driven mechanisms involved in tumor resistance to ionizing radiation and chemotherapy and focus on the use of “epi-drugs” to counteract cancer-driven histone modifications.

DIRECTOR

Rogerio Castilho, DDS, MS, PhD

Principal Investigator

Education
2003-2010 Post-Doctoral Fellowship, National Institutes of Health (NIDCR)
2001-2003 PhD University of Sao Paulo, Brazil
1999-2000 MSc University of Sao Paulo, Brazil
1999 Certificate in Oral Pathology, Sao Leopoldo Mandic, Brazil
1992-1995 DDS Pontific Catholic University of Campinas, Campinas, Brazil
Academic Appointment
2010 - present Assistant Professor
University of Michigan
School of Dentistry
Division of Oral Pathology/Medicine/Radiology
Department of Periodontics and Oral Medicine
Ann Arbor, MI, USA
Certificates and Licenses
1995 Brazilian Dental License - National Council of Dentistry, Brazil Sao Paulo State Dental License (CROSP)
1999 Certificate in Oral Pathology - Advanced Dental Education Sao Leopoldo Mandic, Sao Paulo, Brazil
2014 State of Michigan Clinical Academic Limited License
Editorial Board
2016 Journal of Dental Research

PUBLICATIONS

The most recent publications reported below from pubmed. Visit Dr. Castilho's pubmed page for the complete list of publications.

When epigenetics meets bioengineering-A material characteristics and surface topography perspective.

Related Articles

When epigenetics meets bioengineering-A material characteristics and surface topography perspective.

J Biomed Mater Res B Appl Biomater. 2017 Jul 25;:

Authors: Larsson L, Pilipchuk SP, Giannobile WV, Castilho RM

Abstract
The field of tissue engineering and regenerative medicine (TE/RM) involves regeneration of tissues and organs using implantable biomaterials. The term epigenetics refers to changes in gene expression that are not encoded in the DNA sequence, leading to remodeling of the chromatin and activation or inactivation of gene expression. Recently, studies have demonstrated that these modifications are influenced not only by biological cues but also by mechanical and topographical signals. This review highlights the current knowledge on emerging approaches in TE/RM with a focus on the effect of materials and topography on the epigenetic expression pattern in cells with potential impacts on modulating regenerative biology. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2017.

PMID: 28741893 [PubMed - as supplied by publisher]

Digital Version

PROJECTS

Cancer Biology – Salivary Gland Tumors

Cancer Biology – Head and Neck Squamous Cell Carcinoma (HNSCC)

Epithelial Biology – Periodontal Disease

Epithelial Biology – Titanium Toxicity

Epithelial Biology – Wound Healing


LAB PERSONNEL

Rogerio M. Castilho, DDS, MS, Ph.D

Principal Investigator
rcastilh@gmail.com

Eduardo J. Gaio, DDS, MS, PhD

Visiting Professor, Laboratory of Epithelial Biology
egaio@umich.edu

Fernando Suarez Lopez del Amo, DDS

DDS candidate, Laboratory of Epithelial Biology
fsuarez@umich.edu

Carlos Andres Garaicoa, DDS

DDS candidate, Laboratory of Epithelial Biology
garaicoa@umich.edu

Liana Preto Webber, DDS, MS

Visiting Scholar, Laboratory of Epithelial Biology
lpretowe@umich.edu

Cuong Nguyen

DDS candidate, Laboratory of Epithelial Biology
cpnguyen@umich.edu

Allan Baker

Visiting Scholar, Laboratory of Epithelial Biology
aljbaker@umich.edu

Aaron Shin

Visiting Scholar, Laboratory of Epithelial Biology
akshin@umich.edu

Carlos V. Nascimento Filho

Visiting Scholar, Laboratory of Epithelial Biology

Leonardo Reis

Visiting Scholar, Laboratory of Epithelial Biology

Renata Markman

Visiting Scholar, Laboratory of Epithelial Biology
View the Lab Alumni

LAB ALUMNI

Luciana O. Almeida, Ph.D.

Research Fellow, Laboratory of Epithelial Biology
lucianao@umich.edu

Joao Artur Ricieri Brito, DDS, Ph.D.

Visiting Scholar, Laboratory of Epithelial Biology
joaoarbrito@gmail.com

Carolina Siviero Dillenburg, DDS, MS

Visiting Student, Laboratory of Epithelial Biology
carolsd@gmail.com

Pablo Galindo-Moreno, DDS, Ph.D.

Visiting Professor, Laboratory of Epithelial Biology
pgalindo@ugr.es

Fernanda Giudice, DDS, MS

Visiting Scholar, Laboratory of Epithelial Biology
fernandagiudice@yahoo.com.br

Douglas M. Guimarães, DDS, Ph.D.

Visiting Scholar, Laboratory of Epithelial Biology
douglas_guima@hotmail.com

Luciana Kauer, Ph.D.

Research Fellow, Laboratory of Epithelial Biology
lukauer@umich.edu

Manoela Domingues Martins, DDS, MS, Ph.D.

Visiting Professor, Laboratory of Epithelial Biology
manomartins@gmail.com

Marco Antonio Trevizani Martins, DDS, MS, Ph.D.

Visiting Professor, Laboratory of Epithelial Biology
marcotm@umich.edu

Ana Carolina Pellicioli, DDS, MS.

Visiting Student, Laboratory of Epithelial Biology
anacarolinapellicioli@gmail.com

Vivian Petersen Wagner, DDS, MS

Visiting Scholar, Laboratory of Epithelial Biology
petersev@umich.edu
View the Current Lab Personnel

CONTACT

Castilho Lab
1011 N. University, Room 2228 A, B, C
School of Dentistry University of Michigan
Ann Arbor, MI 48109-1078
734-647-2150
rcastilh@umich.edu